The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
Abeona Therapeutics Inc.COM00289Y10727,9602,184,364SH SOLE 2,184,36400
ACADIA Pharmaceuticals Inc.COM004225108590,39628,439,114SH SOLE 28,439,11400
Acceleron Pharma Inc.COM00434H1084,80283,900SH SOLE 83,90000
Achillion Pharmaceuticals, Inc.COM00448Q2016,0351,639,948SH SOLE 1,639,94800
Adamas Pharmaceuticals, Inc.COM00548A1063,456172,630SH SOLE 172,63000
Aeglea BioTherapeutics, Inc.COM00773J10313,2821,387,872SH SOLE 1,387,87200
Aevi Genomic Medicine, Inc.COM00835P1054,8593,950,419SH SOLE 3,950,41900
Affimed N.V.COMN01045108870200,000SH SOLE 200,00000
Aimmune Therapeutics, Inc.COM00900T10718,384673,908SH SOLE 673,90800
Albireo Pharma, Inc.COM01345P1068,240250,000SH SOLE 250,00000
Alexion Pharmaceuticals, Inc.COM0153511091,189,3558,555,894SH SOLE 8,555,89400
Alkermes plcSHSG017671054,255100,251SH SOLE 100,25100
Amarin Corporation plcSPONSORED ADR023111206554,31134,069,509SH SOLE 34,069,50900
AnaptysBio, Inc.COM03272410611,283113,086SH SOLE 113,08600
Apellis Pharmaceuticals, Inc.COM03753U1063,486196,078SH SOLE 196,07800
Aquestive Therapeutics, Inc.COM03843E1041,74499,600SH SOLE 99,60000
Aquinox Pharmaceuticals, Inc.COM03842B10132,03710,934,154SH SOLE 10,934,15400
Arcus Biosciences, Inc.COM03969F1091,694121,534SH SOLE 121,53400
argenx SESPONSORED ADR04016X10177,3231,019,557SH SOLE 1,019,55700
Array BioPharma Inc.COM04269X10585,9745,656,196SH SOLE 5,656,19600
Arrowhead Pharmaceuticals, Inc.COM04280A1005,895307,496SH SOLE 307,49600
Ascendis Pharma A/SSPONSORED ADR04351P101201,0552,837,352SH SOLE 2,837,35200
Assembly Biosciences, Inc.COM0453961085,519148,587SH SOLE 148,58700
Audentes Therapeutics, Inc.COM05070R10415,568393,222SH SOLE 393,22200
Autolus Therapeutics plcSPON ADS05280R1007,216235,294SH SOLE 235,29400
BeiGene, Ltd.SPONSORED ADR07725L1022,059,72111,959,824SH SOLE 11,959,82400
Bellicum Pharmaceuticals, Inc.COM07948110716,4952,677,818SH SOLE 2,677,81800
BioCryst Pharmaceuticals, Inc.COM09058V103115,23715,103,081SH SOLE 15,103,08100
BioMarin Pharmaceutical Inc.COM09061G101735,3327,583,084SH SOLE 7,583,08400
bluebird bio, Inc.COM09609G1008,67859,441SH SOLE 59,44100
Catalyst Pharmaceuticals, Inc.COM14888U10110,9622,900,000SH SOLE 2,900,00000
Cerus CorporationCOM15708510177,50710,749,937SH SOLE 10,749,93700
ChemoCentryx, Inc.COM16383L1065,233414,029SH SOLE 414,02900
Clementia Pharmaceuticals Inc.COM18557510721,5601,933,624SH SOLE 1,933,62400
ContraFect CorporationCOM21232610214,8077,153,076SH SOLE 7,153,07600
Constellation Pharmaceuticals, Inc.COM210373106897133,333SH SOLE 133,33300
Crinetics Pharmaceuticals, Inc.COM22663K1073,760131,250SH SOLE 131,25000
CymaBay Therapeutics, Inc.COM23257D10354,4884,917,700SH SOLE 4,917,70000
DBV Technologies S.A.SPONSORED ADR23306J101123,7455,509,560SH SOLE 5,509,56000
Dynavax Technologies CorporationCOM26815820193075,000SH SOLE 75,00000
Endocyte, Inc.COM29269A10245,2542,548,069SH SOLE 2,548,06900
ERYTECH Pharma S.A.SPONSORED ADR29604W1089,3071,085,969SH SOLE 1,085,96900
Foamix Pharmaceuticals Ltd.SHSM461351053,943688,075SH SOLE 688,07500
Forty Seven, Inc.COM34983P1043,730250,000SH SOLE 250,00000
Fulgent Genetics, Inc.COM359664109491125,000SH SOLE 125,00000
G1 Therapeutics, Inc.COM3621LQ1096,653127,236SH SOLE 127,23600
Galapagos NVSPONSORED ADR36315X10126,667237,191SH SOLE 237,19100
Galmed Pharmaceuticals Ltd.SHSM472381064,401324,094SH SOLE 324,09400
Genomic Health, Inc.COM37244C101968,40213,790,970SH SOLE 13,790,97000
GW Pharmaceuticals plcADS36197T10368,526396,700SH SOLE 396,70000
Halozyme Therapeutics, Inc.COM40637H1098,176449,969SH SOLE 449,96900
Heron Therapeutics, Inc.COM427746102159,0515,025,298SH SOLE 5,025,29800
Idera Pharmaceuticals, Inc.COM45168K40543,0704,833,897SH SOLE 4,833,89700
Incyte CorporationCOM45337C1022,366,08034,251,309SH SOLE 34,251,30900
Infinity Pharmaceuticals, Inc.COM45665G3031,573580,400SH SOLE 580,40000
InflaRx N.V.COMN448211016,143178,987SH SOLE 178,98700
Insmed IncorporatedCOM PAR $.0145766930737,4471,851,982SH SOLE 1,851,98200
Intellia Therapeutics, Inc.COM45826J1055,510192,538SH SOLE 192,53800
Invitae CorporationCOM46185L103140,5228,399,411SH SOLE 8,399,41100
Kiniksa Pharmaceuticals, Ltd.COM CL AG5269C10176,5003,000,000SH SOLE 3,000,00000
Krystal Biotech, Inc.COM5011471022,016114,674SH SOLE 114,67400
La Jolla Pharmaceutical CompanyCOM PAR $.0001 25034596043,114154,675SH SOLE 154,67500
Madrigal Pharmaceuticals, Inc.COM558868105250,3771,169,278SH SOLE 1,169,27800
Menlo Therapeutics Inc.COM5868581026,895700,000SH SOLE 700,00000
Merus N.V.COMN5749R10022,8991,160,014SH SOLE 1,160,01400
Mirati Therapeutics, Inc.COM60468T105118,3842,513,462SH SOLE 2,513,46200
Molecular Templates, Inc.COM6085501091,370254,230SH SOLE 254,23000
Momenta Pharmaceuticals, Inc.COM60877T1008,114308,500SH SOLE 308,50000
MyoKardia, Inc.COM62857M10523,290357,215SH SOLE 357,21500
Neurocrine Biosciences, Inc.COM64125C109116,142944,624SH SOLE 944,62400
Novavax, Inc.COM6700021048,8704,718,318SH SOLE 4,718,31800
Ovid Therapeutics Inc.COM6904691011,260222,139SH SOLE 222,13900
Principia Biopharma Inc.COM74257L10852,2401,787,807SH SOLE 1,787,80700
Proteon Therapeutics, Inc.COM74371L109582298,591SH SOLE 298,59100
Ra Pharmaceuticals, Inc.COM74933V1083,219177,952SH SOLE 177,95200
Rhythm Pharmaceuticals, Inc.COM76243J10578,9982,708,200SH SOLE 2,708,20000
Ritter Pharmaceuticals, Inc.COM767836307521279,999SH SOLE 279,99900
Sage Therapeutics, Inc.COM78667J10880,159567,497SH SOLE 567,49700
Sangamo Therapeutics, Inc.COM80067710621,7621,283,923SH SOLE 1,283,92300
Seattle Genetics, Inc.COM8125781023,936,67251,046,060SH SOLE 51,046,06000
Solid Biosciences Inc.COM83422E10527,736587,884SH SOLE 587,88400
Spark Therapeutics, Inc.COM84652J10375,5041,384,130SH SOLE 1,384,13000
Spring Bank Pharmaceuticals, Inc.COM8494311017,388613,144SH SOLE 613,14400
Sunesis Pharmaceuticals, Inc.COM PAR8673287001,113556,665SH SOLE 556,66500
Syros Pharmaceuticals, Inc.COM87184Q1076,846574,835SH SOLE 574,83500
Tricida, Inc.COM89610F10148,8801,600,000SH SOLE 1,600,00000
Trillium Therapeutics Inc.COM89620X5062,931505,262SH SOLE 505,26200
uniQure N.V.SHSN9006410122,016605,000SH SOLE 605,00000
Versartis, Inc.COM92529L1023,3972,426,310SH SOLE 2,426,31000
Viking Therapeutics, Inc.COM92686J1067,404425,000SH SOLE 425,00000
Xencor, Inc.COM98401F10523,479602,495SH SOLE 602,49500
Y-mAbs Therapeutics, Inc.COM9842411093,984150,000SH SOLE 150,00000
Zymeworks Inc.COM98985W10220,5841,311,085SH SOLE 1,311,08500
BioMarin Pharmaceutical Inc.NOTE 0.75% 10/15/201809061GAE112,59912,228,000SH SOLE 12,228,00000
BioMarin Pharmaceutical Inc.NOTE 0.599% 8/1/202409061GAH415,81815,000,000SH SOLE 15,000,00000
Corsicanto II Designated Activity CompanyNOTE 3.5% 1/5/2047220485AB241,74810,000,000SH SOLE 10,000,00000
Neurocrine Biosciences, Inc.NOTE 2.25% 5/15/202464125CAD117,06210,000,000SH SOLE 10,000,00000