0001104659-24-061996.txt : 20240515 0001104659-24-061996.hdr.sgml : 20240515 20240515163731 ACCESSION NUMBER: 0001104659-24-061996 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20240331 FILED AS OF DATE: 20240515 DATE AS OF CHANGE: 20240515 EFFECTIVENESS DATE: 20240515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 ORGANIZATION NAME: IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 24951923 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false false false 0001263508 XXXXXXXX 03-31-2024 03-31-2024 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 000158149 801-73446 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 05-15-2024 0 87 7971707022 INFORMATION TABLE 2 infotable.xml 2seventy bio, Inc. COMMON STOCK 901384107 13361764 2497526 SH SOLE 2497526 0 0 4D Molecular Therapeutics, Inc. COM 35104E100 3186000 100000 SH SOLE 100000 0 0 AbCellera Biologics Inc. COM 00288U106 124691149 27525640 SH SOLE 27525640 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 792566676 42864612 SH SOLE 42864612 0 0 Achilles Therapeutics plc SPONSORED ADS 00449L102 1510969 1208775 SH SOLE 1208775 0 0 Acrivon Therapeutics, Inc. COMMON STOCK 004890109 378128 52885 SH SOLE 52885 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 17043495 10787022 SH SOLE 10787022 0 0 Aerovate Therapeutics, Inc. COM 008064107 49692888 1680517 SH SOLE 1680517 0 0 Akero Therapeutics, Inc. COM 00973Y108 68535558 2713205 SH SOLE 2713205 0 0 Aligos Therapeutics, Inc. COM 01626L105 2034872 2076400 SH SOLE 2076400 0 0 Alpine Immune Sciences, Inc. COM 02083G100 3233752 81578 SH SOLE 81578 0 0 argenx SE SPONSORED ADR 04016X101 59536370 151215 SH SOLE 151215 0 0 Athira Pharma, Inc. COM 04746L104 8641431 3153807 SH SOLE 3153807 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 1652869802 10568897 SH SOLE 10568897 0 0 Bicycle Therapeutics plc SPONSORED ADS 088786108 123076293 4942823 SH SOLE 4942823 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 51440974 10126176 SH SOLE 10126176 0 0 Biomea Fusion, Inc. COM 09077A106 31528788 2108949 SH SOLE 2108949 0 0 Cabaletta Bio, Inc. COM 12674W109 227427 13331 SH SOLE 13331 0 0 Celcuity Inc. COM 15102K100 33533525 1552478 SH SOLE 1552478 0 0 Celldex Therapeutics, Inc. COM 15117B202 10393619 247644 SH SOLE 247644 0 0 Century Therapeutics, Inc. COM 15673T100 3333383 797460 SH SOLE 797460 0 0 Cerevel Therapeutics Holdings, Inc. COM 15678U128 67632000 1600000 SH SOLE 1600000 0 0 Cerus Corporation COM 157085101 36812171 19477339 SH SOLE 19477339 0 0 Compass Therapeutics, Inc. COM 20454B104 3084107 1557630 SH SOLE 1557630 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 10947545 14614264 SH SOLE 14614264 0 0 Denali Therapeutics Inc. COM 24823R105 76574381 3731695 SH SOLE 3731695 0 0 Design Therapeutics, Inc. COM 25056L103 6698344 1662120 SH SOLE 1662120 0 0 Dyne Therapeutics, Inc. COM 26818M108 8091150 285000 SH SOLE 285000 0 0 Edgewise Therapeutics, Inc. COM 28036F105 106522676 5840059 SH SOLE 5840059 0 0 Enliven Therapeutics, Inc. COM 29337E102 2019912 114833 SH SOLE 114833 0 0 Entrada Therapeutics, Inc. COM 29384C108 68948655 4865819 SH SOLE 4865819 0 0 Fate Therapeutics, Inc. COM 31189P102 13345449 1818181 SH SOLE 1818181 0 0 Foghorn Therapeutics Inc. COM 344174107 302131 45027 SH SOLE 45027 0 0 Generation Bio Co. COM 37148K100 1510861 371219 SH SOLE 371219 0 0 HOOKIPA Pharma Inc. COM 43906K100 5787244 8128151 SH SOLE 8128151 0 0 IDEAYA Biosciences, Inc. COM 45166A102 46605957 1062123 SH SOLE 1062123 0 0 IGM Biosciences, Inc. COM 449585108 39452307 4088322 SH SOLE 4088322 0 0 Immatics N.V. SHS N44445109 67720113 6443398 SH SOLE 6443398 0 0 Immunocore Holdings plc ADS 45258D105 98495670 1515318 SH SOLE 1515318 0 0 Immunovant, Inc. COM 45258J102 13732041 425009 SH SOLE 425009 0 0 Incyte Corporation COM 45337C102 2061155515 36179665 SH SOLE 36179665 0 0 Insmed Incorporated COM PAR $.01 457669307 9305590 343000 SH SOLE 343000 0 0 KALA BIO, Inc. COM 483119202 2124906 266613 SH SOLE 266613 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 55432954 2809577 SH SOLE 2809577 0 0 Kodiak Sciences Inc. COM 50015M109 91053177 17310490 SH SOLE 17310490 0 0 Krystal Biotech, Inc. COM 501147102 30236357 169934 SH SOLE 169934 0 0 Kymera Therapeutics, Inc. COM 501575104 241036306 5995928 SH SOLE 5995928 0 0 Leap Therapeutics, Inc. COM 52187K200 3117986 1172175 SH SOLE 1172175 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 526014858 1969798 SH SOLE 1969798 0 0 Mersana Therapeutics, Inc. COM 59045L106 4865795 1086115 SH SOLE 1086115 0 0 Mirum Pharmaceuticals, Inc. COM 604749101 4784757 190476 SH SOLE 190476 0 0 Monte Rosa Therapeutics, Inc. COM 61225M102 34658470 4916095 SH SOLE 4916095 0 0 Mural Oncology plc ORD SHS G63365103 1088040 222503 SH SOLE 222503 0 0 Neumora Therapeutics, Inc. COM 640979100 8715451 633851 SH SOLE 633851 0 0 Neurogene Inc. COM 64135M105 23211164 456015 SH SOLE 456015 0 0 NewAmsterdam Pharma Company N.V. ORDINARY SHARES N62509109 2289959 96827 SH SOLE 96827 0 0 Nurix Therapeutics, Inc. COM 67080M103 57067238 3882125 SH SOLE 3882125 0 0 Opthea Limited SPONSORED ADS 68386J208 8950865 2177826 SH SOLE 2177826 0 0 Perspective Therapeutics, Inc. COM 46489V104 178247 149787 SH SOLE 149787 0 0 Pfizer Inc. COM 717081103 971250 35000 SH SOLE 35000 0 0 PMV Pharmaceuticals, Inc. COM 69353Y103 547441 322024 SH SOLE 322024 0 0 Praxis Precision Medicines, Inc. COM 74006W207 8026144 131533 SH SOLE 131533 0 0 Prelude Therapeutics Inc. COM 74065P101 47986926 10123824 SH SOLE 10123824 0 0 Prime Medicine, Inc. COM 74168J101 7199262 1028466 SH SOLE 1028466 0 0 Protara Therapeutics, Inc. COM STK 74365U107 800681 199671 SH SOLE 199671 0 0 Relay Therapeutics, Inc. COM 75943R102 9628971 1160117 SH SOLE 1160117 0 0 Replimune Group, Inc. COM 76029N106 77985395 9545336 SH SOLE 9545336 0 0 Revolution Medicines, Inc. COM 76155X100 243312295 7549249 SH SOLE 7549249 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 277241155 6398365 SH SOLE 6398365 0 0 Roivant Sciences Ltd. SHS G76279101 78141810 7413834 SH SOLE 7413834 0 0 Sage Therapeutics, Inc. COM 78667J108 7631247 407217 SH SOLE 407217 0 0 Sagimet Biosciences Inc. COM SER A 786700104 7489887 1381898 SH SOLE 1381898 0 0 Sana Biotechnology, Inc. COM 799566104 23809490 2380949 SH SOLE 2380949 0 0 Sera Prognostics, Inc. CLASS A COM 81749D107 49453031 5434399 SH SOLE 5434399 0 0 Stoke Therapeutics, Inc. COM 86150R107 45473981 3368443 SH SOLE 3368443 0 0 Surrozen, Inc. W EXP 8/11/2026 86889P117 25167 833333 SH SOLE 833333 0 0 Talis Biomedical Corporation COM 87424L207 4447826 508323 SH SOLE 508323 0 0 Tango Therapeutics, Inc. COM 87583X109 5955000 750000 SH SOLE 750000 0 0 Taysha Gene Therapies, Inc. COM SHS 877619106 11493650 4004756 SH SOLE 4004756 0 0 TScan Therapeutics, Inc. COM 89854M101 22111248 2784792 SH SOLE 2784792 0 0 Tyra Biosciences, Inc. COM 90240B106 173955 10607 SH SOLE 10607 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 68473079 1466547 SH SOLE 1466547 0 0 Vaxcyte, Inc. COM 92243G108 3339334 48885 SH SOLE 48885 0 0 Verve Therapeutics, Inc. COM 92539P101 22463518 1691530 SH SOLE 1691530 0 0 vTv Therapeutics, Inc. CL A 918385204 2289798 97314 SH SOLE 97314 0 0 Xencor, Inc. COM 98401F105 12070388 545431 SH SOLE 545431 0 0 Xenon Pharmaceuticals Inc. COM 98420N105 42777881 993679 SH SOLE 993679 0 0