Chief Financial Officer

0001104659-22-091286.txt : 20220815 0001104659-22-091286.hdr.sgml : 20220815 20220815165612 ACCESSION NUMBER: 0001104659-22-091286 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20220630 FILED AS OF DATE: 20220815 DATE AS OF CHANGE: 20220815 EFFECTIVENESS DATE: 20220815 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 221166427 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 06-30-2022 06-30-2022 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey Chief Financial Officer 212-339-5690 /s/ Alexandra Toohey New York NY 08-15-2022 0 117 17626987 INFORMATION TABLE 2 infotable.xml 2seventy bio, Inc. COMMON STOCK 901384107 27228 2062744 SH SOLE 2062744 0 0 AbCellera Biologics Inc. COM 00288U106 111294 10450180 SH SOLE 10450180 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 590702 41923486 SH SOLE 41923486 0 0 Achilles Therapeutics plc SPONSORED ADS 00449L102 6530 2591366 SH SOLE 2591366 0 0 Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 16712 9830877 SH SOLE 9830877 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 1722 3410106 SH SOLE 3410106 0 0 Aerovate Therapeutics, Inc. COM 008064107 32354 2070010 SH SOLE 2070010 0 0 Affimed N.V. COM N01045108 18273 6596830 SH SOLE 6596830 0 0 Akero Therapeutics, Inc. COM 00973Y108 1119 118378 SH SOLE 118378 0 0 Alector, Inc. COM 014442107 2431 239228 SH SOLE 239228 0 0 Aligos Therapeutics, Inc. COM 01626L105 2512 2076400 SH SOLE 2076400 0 0 Alkermes plc SHS G01767105 44685 1500000 SH SOLE 1500000 0 0 Allakos Inc. COM 01671P100 2201 703050 SH SOLE 703050 0 0 Altimmune, Inc. COM 02155H200 24282 2075403 SH SOLE 2075403 0 0 Amarin Corporation plc SPONSORED ADR 023111206 31543 21169805 SH SOLE 21169805 0 0 AnaptysBio, Inc. COM 032724106 8672 427179 SH SOLE 427179 0 0 argenx SE SPONSORED ADR 04016X101 424178 1119557 SH SOLE 1119557 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 451103 4852655 SH SOLE 4852655 0 0 Atara Biotherapeutics, Inc. COM 046513107 5797 744186 SH SOLE 744186 0 0 Athira Pharma, Inc. COM 04746L104 3175 1040834 SH SOLE 1040834 0 0 Atreca, Inc. CL A COM 04965G109 6324 3532760 SH SOLE 3532760 0 0 aTyr Pharma, Inc. COM 002120202 1060 374395 SH SOLE 374395 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 1888611 11668897 SH SOLE 11668897 0 0 Bellicum Pharmaceuticals, Inc. COM 079481404 296 249123 SH SOLE 249123 0 0 BioAtla, Inc. COM 09077B104 2351 825000 SH SOLE 825000 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 134480 12710818 SH SOLE 12710818 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 631510 7620494 SH SOLE 7620494 0 0 Biomea Fusion, Inc. COM 09077A106 25213 2104559 SH SOLE 2104559 0 0 bluebird bio, Inc. COM 09609G100 10349 2499715 SH SOLE 2499715 0 0 Burning Rock Biotech Limited SPONSORED ADS 12233L107 609 209131 SH SOLE 209131 0 0 Cabaletta Bio, Inc. COM 12674W109 702 662063 SH SOLE 662063 0 0 Centessa Pharmaceuticals plc SPONSORED ADS 152309100 5490 1127273 SH SOLE 1127273 0 0 Cerus Corporation COM 157085101 84997 16067558 SH SOLE 16067558 0 0 ChemoCentryx, Inc. COM 16383L106 44422 1792657 SH SOLE 1792657 0 0 Chinook Therapeutics, Inc. COM 16961L106 44321 2534102 SH SOLE 2534102 0 0 Crinetics Pharmaceuticals, Inc. COM 22663K107 15433 827480 SH SOLE 827480 0 0 CymaBay Therapeutics, Inc. COM 23257D103 6403 2170464 SH SOLE 2170464 0 0 Cyteir Therapeutics, Inc. COM 23284P103 7904 2643640 SH SOLE 2643640 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 37266 14614264 SH SOLE 14614264 0 0 Denali Therapeutics Inc. COM 24823R105 17327 588738 SH SOLE 588738 0 0 Design Therapeutics, Inc. COM 25056L103 20113 1436636 SH SOLE 1436636 0 0 DICE Therapeutics, Inc. COM 23345J104 9129 588235 SH SOLE 588235 0 0 Edgewise Therapeutics, Inc. COM 28036F105 3980 500000 SH SOLE 500000 0 0 Entrada Therapeutics, Inc. COM 29384C108 59266 4865819 SH SOLE 4865819 0 0 Epizyme, Inc. COM 29428V104 1470 1000000 SH SOLE 1000000 0 0 Evofem Biosciences, Inc. COM 30048L203 2919 2583616 SH SOLE 2583616 0 0 FibroGen, Inc. COM 31572Q808 8614 815718 SH SOLE 815718 0 0 Foghorn Therapeutics Inc. COM 344174107 612 45027 SH SOLE 45027 0 0 Forma Therapeutics Holdings, Inc. SHS 34633R104 13951 2024876 SH SOLE 2024876 0 0 Fulgent Genetics, Inc. COM 359664109 10985 201444 SH SOLE 201444 0 0 Genetron Holdings Limited ADS 37186H100 774 455306 SH SOLE 455306 0 0 Global Blood Therapeutics, Inc. COM 37890U108 119253 3732502 SH SOLE 3732502 0 0 Harmony Biosciences Holdings, Inc. COM 413197104 6028 123600 SH SOLE 123600 0 0 Heron Therapeutics, Inc. COM 427746102 22687 8131678 SH SOLE 8131678 0 0 HOOKIPA Pharma Inc. COM 43906K100 3913 2400481 SH SOLE 2400481 0 0 Horizon Therapeutics Public Ltd Co SHS G46188101 91605 1148504 SH SOLE 1148504 0 0 IGM Biosciences, Inc. COM 449585108 56905 3156102 SH SOLE 3156102 0 0 Immatics N.V. SHS N44445109 38531 4423731 SH SOLE 4423731 0 0 Immunocore Holdings plc ADS 45258D105 94048 2520730 SH SOLE 2520730 0 0 Incyte Corporation COM 45337C102 2746628 36154117 SH SOLE 36154117 0 0 Inozyme Pharma, Inc. COM 45790W108 510 106999 SH SOLE 106999 0 0 Insmed Incorporated COM PAR $.01 457669307 42516 2156001 SH SOLE 2156001 0 0 Instil Bio, Inc. COM 45783C101 17989 3893700 SH SOLE 3893700 0 0 Invitae Corporation COM 46185L103 24091 9873488 SH SOLE 9873488 0 0 iTeos Therapeutics, Inc. COM 46565G104 3097 150346 SH SOLE 150346 0 0 Karuna Therapeutics, Inc. COM 48576A100 8851 69966 SH SOLE 69966 0 0 Kezar Life Sciences, Inc. COM 49372L100 512 61946 SH SOLE 61946 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 27128 2799577 SH SOLE 2799577 0 0 Kodiak Sciences Inc. COM 50015M109 132252 17310490 SH SOLE 17310490 0 0 Krystal Biotech, Inc. COM 501147102 53036 807735 SH SOLE 807735 0 0 Kymera Therapeutics, Inc. COM 501575104 56704 2879825 SH SOLE 2879825 0 0 Leap Therapeutics, Inc. COM 52187K101 644 559705 SH SOLE 559705 0 0 Legend Biotech Corporation SPONSORED ADS 52490G102 47116 856658 SH SOLE 856658 0 0 LogicBio Therapeutics, Inc. COM 54142F102 158 451478 SH SOLE 451478 0 0 MacroGenics, Inc. COM 556099109 2633 892579 SH SOLE 892579 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 107314 1499213 SH SOLE 1499213 0 0 Merus N.V. COM N5749R100 22536 995397 SH SOLE 995397 0 0 Mirati Therapeutics, Inc. COM 60468T105 94639 1409784 SH SOLE 1409784 0 0 Natera, Inc. COM 632307104 3544 100000 SH SOLE 100000 0 0 Neoleukin Therapeutics, Inc. COM 64049K104 3936 3821740 SH SOLE 3821740 0 0 NexImmune, Inc. COM 65344D109 32 20000 SH SOLE 20000 0 0 NGM Biopharmaceuticals, Inc. COM 62921N105 709 55294 SH SOLE 55294 0 0 Nkarta, Inc. COM 65487U108 4928 400000 SH SOLE 400000 0 0 Nurix Therapeutics, Inc. COM 67080M103 49187 3882125 SH SOLE 3882125 0 0 Opthea Limited SPONSORED ADS 68386J208 16986 2696191 SH SOLE 2696191 0 0 Otonomy, Inc. COM 68906L105 17498 8412634 SH SOLE 8412634 0 0 Pacific Biosciences of California, Inc. COM 69404D108 24067 5444963 SH SOLE 5444963 0 0 Passage Bio, Inc. COM 702712100 276 117161 SH SOLE 117161 0 0 Prelude Therapeutics Inc. COM 74065P101 52846 10123824 SH SOLE 10123824 0 0 Protara Therapeutics, Inc. COM STK 74365U107 585 199671 SH SOLE 199671 0 0 Reata Pharmaceuticals, Inc. CL A 75615P103 6807 223976 SH SOLE 223976 0 0 Relmada Therapeutics, Inc. COM 75955J402 9402 495113 SH SOLE 495113 0 0 Replimune Group, Inc. COM 76029N106 62772 3591081 SH SOLE 3591081 0 0 Revolution Medicines, Inc. COM 76155X100 4331 222222 SH SOLE 222222 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 17119 4125062 SH SOLE 4125062 0 0 Seagen Inc. COM 81181C104 8300656 46912266 SH SOLE 46912266 0 0 Sera Prognostics, Inc. CLASS A COM 81749D107 331 201562 SH SOLE 201562 0 0 Surrozen, Inc. COM 86889P109 7500 2500000 SH SOLE 2500000 0 0 Surrozen, Inc. W EXP 8/11/2026 86889P117 159 833333 SH SOLE 833333 0 0 Syndax Pharmaceuticals, Inc. COM 87164F105 2130 110729 SH SOLE 110729 0 0 Talis Biomedical Corporation COM 87424L108 6191 7624835 SH SOLE 7624835 0 0 Tango Therapeutics, Inc. COM 87583X109 3398 750000 SH SOLE 750000 0 0 TCR2 Therapeutics Inc. COM 87808K106 2184 753064 SH SOLE 753064 0 0 Travere Therapeutics, Inc. COM 89422G107 79959 3300009 SH SOLE 3300009 0 0 Tricida, Inc. COM 89610F101 14550 1503090 SH SOLE 1503090 0 0 TScan Therapeutics, Inc. COM 89854M101 8758 2784792 SH SOLE 2784792 0 0 Ultragenyx Pharmaceutical Inc. COM 90400D108 28098 470974 SH SOLE 470974 0 0 Vera Therapeutics, Inc. CL A 92337R101 4537 333333 SH SOLE 333333 0 0 Verastem, Inc. COM 92337C104 31307 26988898 SH SOLE 26988898 0 0 Verve Therapeutics, Inc. COM 92539P101 21645 1416530 SH SOLE 1416530 0 0 Vincerx Pharma, Inc. COM 92731L106 319 241379 SH SOLE 241379 0 0 Vor Biopharma Inc. COM 929033108 5660 1138768 SH SOLE 1138768 0 0 Xenon Pharmaceuticals Inc. COM 98420N105 22865 751639 SH SOLE 751639 0 0 Zymeworks Inc. COM 98985W102 9055 1708472 SH SOLE 1708472 0 0 Insmed Incorporated Note 0.75% 6/1/2028 457669AB5 33278 40000000 PRN SOLE 40000000 0 0 Invitae Corporation Note 2.0% 9/1/2024 46185LAB9 8087 10300000 PRN SOLE 10300000 0 0 Sarepta Therapeutics, Inc. DBCV 1.5% 11/15/2024 803607AB6 36577 29174000 PRN SOLE 29174000 0 0