0001104659-20-021838.txt : 20200214 0001104659-20-021838.hdr.sgml : 20200214 20200214162602 ACCESSION NUMBER: 0001104659-20-021838 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20191231 FILED AS OF DATE: 20200214 DATE AS OF CHANGE: 20200214 EFFECTIVENESS DATE: 20200214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: BAKER BROS. ADVISORS LP CENTRAL INDEX KEY: 0001263508 IRS NUMBER: 134093645 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-10519 FILM NUMBER: 20620545 BUSINESS ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 BUSINESS PHONE: 2123395600 MAIL ADDRESS: STREET 1: 860 WASHINGTON STREET STREET 2: 3RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10014 FORMER COMPANY: FORMER CONFORMED NAME: BAKER BROS ADVISORS LLC DATE OF NAME CHANGE: 20030911 13F-HR 1 primary_doc.xml 13F-HR LIVE false false false 0001263508 XXXXXXXX 12-31-2019 12-31-2019 false BAKER BROS. ADVISORS LP

860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014

13F HOLDINGS REPORT 028-10519 N Alexandra Toohey 212-339-5690 /s/ Alexandra Toohey New York NY 02-14-2020 0 99 18809854 INFORMATION TABLE 2 infotable.xml Abeona Therapeutics Inc. COM 00289Y107 7483 2288235 SH SOLE 2288235 0 0 ACADIA Pharmaceuticals Inc. COM 004225108 1747759 40854586 SH SOLE 40854586 0 0 Adamas Pharmaceuticals, Inc. COM 00548A106 654 172630 SH SOLE 172630 0 0 Adaptive Biotechnologies Corporation COM 00650F109 33373 1115411 SH SOLE 1115411 0 0 Aeglea BioTherapeutics, Inc. COM 00773J103 13092 1713604 SH SOLE 1713604 0 0 Affimed N.V. COM N01045108 548 200000 SH SOLE 200000 0 0 Aimmune Therapeutics, Inc. COM 00900T107 22556 673908 SH SOLE 673908 0 0 Albireo Pharma, Inc. COM 01345P106 6355 250000 SH SOLE 250000 0 0 Alexion Pharmaceuticals, Inc. COM 015351109 893110 8258068 SH SOLE 8258068 0 0 Alkermes plc SHS G01767105 16180 793130 SH SOLE 793130 0 0 Allakos Inc. COM 01671P100 32393 339690 SH SOLE 339690 0 0 Amarin Corporation plc SPONSORED ADR 023111206 739609 34496685 SH SOLE 34496685 0 0 AnaptysBio, Inc. COM 032724106 1838 113086 SH SOLE 113086 0 0 Apellis Pharmaceuticals, Inc. COM 03753U106 15217 496969 SH SOLE 496969 0 0 Aravive, Inc. COM 03890D108 5924 433333 SH SOLE 433333 0 0 Arcus Biosciences, Inc. COM 03969F109 1227 121534 SH SOLE 121534 0 0 argenx SE SPONSORED ADR 04016X101 163659 1019557 SH SOLE 1019557 0 0 Ascendis Pharma A/S SPONSORED ADR 04351P101 471654 3390270 SH SOLE 3390270 0 0 Assembly Biosciences, Inc. COM 045396108 31542 1541618 SH SOLE 1541618 0 0 Atreca, Inc. CL A Common 04965G109 54652 3532760 SH SOLE 3532760 0 0 Audentes Therapeutics, Inc. COM 05070R104 48154 804720 SH SOLE 804720 0 0 Aurinia Pharmaceuticals Inc. COM 05156V102 34481 1701929 SH SOLE 1701929 0 0 Autolus Therapeutics plc SPONSORED ADS 05280R100 2069 156773 SH SOLE 156773 0 0 Axsome Therapeutics, Inc. COM 05464T104 85764 829757 SH SOLE 829757 0 0 BeiGene, Ltd. SPONSORED ADR 07725L102 1952203 11777285 SH SOLE 11777285 0 0 Bellicum Pharmaceuticals, Inc. COM 079481107 3454 2677818 SH SOLE 2677818 0 0 BioCryst Pharmaceuticals, Inc. COM 09058V103 37764 10946166 SH SOLE 10946166 0 0 BioMarin Pharmaceutical Inc. COM 09061G101 641675 7589294 SH SOLE 7589294 0 0 bluebird bio, Inc. COM 09609G100 3510 40000 SH SOLE 40000 0 0 Cabaletta Bio, Inc. COM 12674W109 8890 636363 SH SOLE 636363 0 0 Catalyst Pharmaceuticals, Inc. COM 14888U101 5032 1341902 SH SOLE 1341902 0 0 Cerus Corporation COM 157085101 45365 10749937 SH SOLE 10749937 0 0 ChemoCentryx, Inc. COM 16383L106 29228 739016 SH SOLE 739016 0 0 Constellation Pharmaceuticals, Inc. COM 210373106 6281 133333 SH SOLE 133333 0 0 Crinetics Pharmaceuticals, Inc. COM 22663K107 4391 175000 SH SOLE 175000 0 0 CytomX Therapeutics, Inc. COM 23284F105 1615 194377 SH SOLE 194377 0 0 DBV Technologies S.A. SPONSORED ADR 23306J101 156373 14614264 SH SOLE 14614264 0 0 Dynavax Technologies Corporation COM 268158201 429 75000 SH SOLE 75000 0 0 Evofem Biosciences, Inc. COM 30048L104 4670 756813 SH SOLE 756813 0 0 Exact Sciences Corporation COM 30063P105 239134 2585791 SH SOLE 2585791 0 0 Frequency Therapeutics, Inc. COM 35803L108 21587 1231433 SH SOLE 1231433 0 0 Fulgent Genetics, Inc. COM 359664109 7346 569444 SH SOLE 569444 0 0 G1 Therapeutics, Inc. COM 3621LQ109 3363 127236 SH SOLE 127236 0 0 Galapagos NV SPONSORED ADR 36315X101 2704 13072 SH SOLE 13072 0 0 Galmed Pharmaceuticals Ltd. SHS M47238106 1246 215594 SH SOLE 215594 0 0 GW Pharmaceuticals plc ADS 36197T103 38776 370845 SH SOLE 370845 0 0 Harpoon Therapeutics, Inc. COM 41358P106 3169 214285 SH SOLE 214285 0 0 Heron Therapeutics, Inc. COM 427746102 141425 6018104 SH SOLE 6018104 0 0 HOOKIPA Pharma Inc. COM 43906K100 10920 892857 SH SOLE 892857 0 0 IDEAYA Biosciences, Inc. COM 45166A102 1500 200000 SH SOLE 200000 0 0 Idera Pharmaceuticals, Inc. COM PAR 45168K405 8388 4608786 SH SOLE 4608786 0 0 IGM Biosciences, Inc. COM 449585108 119975 3144000 SH SOLE 3144000 0 0 Incyte Corporation COM 45337C102 2792221 31976873 SH SOLE 31976873 0 0 Infinity Pharmaceuticals, Inc. COM 45665G303 557 580400 SH SOLE 580400 0 0 Inflarx N.V. COM N44821101 7043 1778415 SH SOLE 1778415 0 0 Insmed Incorporated COM PAR $.01 457669307 58393 2445265 SH SOLE 2445265 0 0 Intellia Therapeutics, Inc. COM 45826J105 1886 128538 SH SOLE 128538 0 0 Invitae Corporation COM 46185L103 146737 9097165 SH SOLE 9097165 0 0 IVERIC bio, Inc. COM 46583P102 1216 141750 SH SOLE 141750 0 0 Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 30963 2799577 SH SOLE 2799577 0 0 Kodiak Sciences Inc. COM 50015M109 794852 11047289 SH SOLE 11047289 0 0 Krystal Biotech, Inc. COM 501147102 57300 1034674 SH SOLE 1034674 0 0 Leap Therapeutics, Inc. COM 52187K101 1096 978454 SH SOLE 978454 0 0 Madrigal Pharmaceuticals, Inc. COM 558868105 106533 1169278 SH SOLE 1169278 0 0 Marker Therapeutics, Inc. COM 57055L107 4320 1500000 SH SOLE 1500000 0 0 Matinas BioPharma Holdings, Inc. COM 576810105 5975 2632348 SH SOLE 2632348 0 0 Menlo Therapeutics Inc. COM 586858102 3248 700000 SH SOLE 700000 0 0 Merus N.V. COM N5749R100 28688 2037469 SH SOLE 2037469 0 0 Millendo Therapeutics, Inc. COM 60040X103 5617 833333 SH SOLE 833333 0 0 Mirati Therapeutics, Inc. COM 60468T105 168448 1307220 SH SOLE 1307220 0 0 Mirum Pharmaceuticals, Inc. COM 604749101 8173 333333 SH SOLE 333333 0 0 Molecular Templates, Inc. COM 608550109 4429 316730 SH SOLE 316730 0 0 MyoKardia, Inc. COM 62857M105 129315 1774234 SH SOLE 1774234 0 0 Neoleukin Therapeutics, Inc. COM 64049K104 41860 3397740 SH SOLE 3397740 0 0 Neurocrine Biosciences, Inc. COM 64125C109 134819 1254243 SH SOLE 1254243 0 0 NextCure, Inc. COM 65343E108 8450 150000 SH SOLE 150000 0 0 NGM Biopharmaceuticals, Inc. COM 62921N105 4623 250000 SH SOLE 250000 0 0 Orchard Therapeutics plc ADS 68570P101 5578 405702 SH SOLE 405702 0 0 Principia Biopharma Inc. COM 74257L108 97944 1787957 SH SOLE 1787957 0 0 Protagonist Therapeutics, Inc. COM 74366E102 8279 1174282 SH SOLE 1174282 0 0 Ra Pharmaceuticals, Inc. COM 74933V108 98264 2093839 SH SOLE 2093839 0 0 Reata Pharmaceuticals, Inc. CL A 75615P103 8378 40983 SH SOLE 40983 0 0 Rhythm Pharmaceuticals, Inc. COM 76243J105 62180 2708200 SH SOLE 2708200 0 0 Sangamo Therapeutics, Inc. COM 800677106 8369 999823 SH SOLE 999823 0 0 Seattle Genetics, Inc. COM 812578102 5719544 50057277 SH SOLE 50057277 0 0 Spring Bank Pharmaceuticals, Inc. COM 849431101 969 613144 SH SOLE 613144 0 0 Sunesis Pharmaceuticals, Inc. COM 867328700 188 556665 SH SOLE 556665 0 0 Syros Pharmaceuticals, Inc. COM 87184Q107 4769 690167 SH SOLE 690167 0 0 Tricida, Inc. COM 89610F101 74344 1969905 SH SOLE 1969905 0 0 Trillium Therapeutics Inc. COM 89620X506 1133 1100000 SH SOLE 1100000 0 0 uniQure N.V. SHS N90064101 37098 517700 SH SOLE 517700 0 0 UroGen Pharma Ltd. COM M96088105 27747 831488 SH SOLE 831488 0 0 Urovant Sciences Ltd. SHS G9381B108 15510 1000000 SH SOLE 1000000 0 0 Viking Therapeutics, Inc. COM 92686J106 3409 425000 SH SOLE 425000 0 0 Xencor, Inc. COM 98401F105 14723 428120 SH SOLE 428120 0 0 Y-mAbs Therapeutics, Inc. COM 984241109 4329 138514 SH SOLE 138514 0 0 Zymeworks Inc. COM 98985W102 77667 1708472 SH SOLE 1708472 0 0 BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 15841 15000000 PRN SOLE 15000000 0 0 Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 47123 30770000 PRN SOLE 30770000 0 0