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License Agreements - Additional Information (Detail) - USD ($)
$ in Millions
1 Months Ended 6 Months Ended
Sep. 30, 2017
Dec. 31, 2021
Dec. 31, 2020
May 31, 2020
Related Party Transaction [Line Items]        
Milestone payments payable amount   $ 20.0    
Kyowa Kirin Co        
Related Party Transaction [Line Items]        
Total upfront payment receivable for grant of rights       $ 100.0
Kyowa Kirin Co | Potential Payments on Achievement of Development Regulatory and Commercial Milestones | Maximum        
Related Party Transaction [Line Items]        
Milestone payment receivable amount   582.5    
Presage License Agreement | Presage Biosciences, Inc.        
Related Party Transaction [Line Items]        
Compensation payable for grant of rights $ 4.9      
Payment for license 2.9      
Presage License Agreement | Presage Biosciences, Inc. | Incremental Payment        
Related Party Transaction [Line Items]        
Compensation payable for grant of rights 2.0      
Presage License Agreement | Presage Biosciences, Inc. | Potential Payments on Achievement of Development Regulatory and Commercial Milestones        
Related Party Transaction [Line Items]        
Milestone payment receivable amount $ 179.0      
Kkc Agreements [Member] | Kyowa Kirin Co        
Related Party Transaction [Line Items]        
Upfront payment   100.0    
Transaction price relating to the performance obligation   191.5    
Expected milestone payment receivable   20.0    
Estimated development cost sharing recovered through earnings   66.3    
Deferred revenue   5.2    
Kkc Agreements [Member] | Kyowa Kirin Co | Ex US License        
Related Party Transaction [Line Items]        
Performance obligation revenue recognised   21.0    
License Obligation Account Transaction Price Allocated   64.5    
Kkc Agreements [Member] | Kyowa Kirin Co | Development Services        
Related Party Transaction [Line Items]        
Contract with customer liability non current   29.5 $ 20.3  
Kkc Agreements [Member] | Kyowa Kirin Co | Maximum        
Related Party Transaction [Line Items]        
Estimated development cost sharing recovered through earnings   $ 152.3