Equity Incentive Plans (Tables)

12 Months Ended

Dec. 31, 2022

Equity Incentive Plans

Schedule of stock-based compensation expense

	Year Ended
	December 31,
	2022		2021		2020
Cost of goods sold	$	133	$	271	$	14
Research and development		372		490		651
Selling and marketing		155		148		108
General and administrative		1,833		2,429		2,045
Total	$	2,493	$	3,338	$	2,818

Schedule of assumptions used to compute employee stock-based compensation

	2022		2021		2020
Risk‑free interest rate	1.71% - 4.22	%	.66% - 1.51	%	.40% - 1.68	%
Expective volatility	107% ‑ 118	%	105% ‑ 106	%	65% ‑ 106	%
Expected dividend yield	0	%	0	%	0	%
Expected life (in years)	6.25		6.25		6.25

Summary of options outstanding, vested and exercisable

			Weighted
		Weighted	Average
		Average	Remaining
		Exercise	Contractual	Aggregate
	Options	Price	Life (Years)	Intrinsic Value
Options outstanding at December 31, 2020	212,946	125.29	6.3
Options granted	64,528	105.00
Options exercised	(3,159)	23.80
Options cancelled/forfeited	(15,170)	264.46
Options outstanding at December 31, 2021	259,145	113.33	6.1
Options granted	187,454	3.97
Options exercised	—	—
Options cancelled/forfeited	(48,781)	97.44
Options outstanding at December 31, 2022	397,818	63.75	7.7	$	6
Options exercisable at December 31, 2022	182,667	113.54	5.7	$	—
Vested and expected to vest at December 31, 2022	397,818			$	6

Schedule of restricted stock activity

		Weighted Average	Aggregate
	Shares	Grant Date Fair Value	Intrinsic Value
Restricted stock units outstanding at December 31, 2020	3,988		$	458
Granted	7,433	67.27
Vested	(3,096)	112.73
Restricted stock units outstanding at December 31, 2021	8,325	—	$	163
Granted	4,690	1.05
Vested	(6,554)	76.30
Restricted stock units outstanding at December 31, 2022	6,461		$	2