Equity Incentive Plans - Stock-Based Compensation (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Equity Incentive Plans
Total stock-based compensation expense	$ 3,630	$ 3,651	$ 3,425
Assumptions used to compute employee stock based compensation under the Black-Scholes option pricing model
Risk-free interest rate (as a percent)	2.57%	2.27%	1.48%
Expective volatility (as a percent)	70.00%	73.90%	75.00%
Expected dividend yield (as a percent)	0.00%	0.00%	0.00%
Expected life (in years)	6 years 3 months	6 years 3 months	6 years 3 months
Common stock options
Equity Incentive Plans
Total stock-based compensation expense	$ 3,630	$ 3,651	$ 3,425
Unrecorded deferred stock-based compensation
Unrecorded deferred stock-based compensation balance related to stock options	$ 3,100
Weighted-average amortization period over which cost is expected to be recognized	1 year 8 months 12 days
Weighted average grant date fair value of options granted (in dollars per share)	$ 1.27
Common stock options \| Research and development
Equity Incentive Plans
Total stock-based compensation expense	$ 1,274	1,184	1,063
Common stock options \| General and administrative
Equity Incentive Plans
Total stock-based compensation expense	$ 2,356	$ 2,467	$ 2,362

No definition available.

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- Definition

Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Unrecognized cost of unvested options awarded to employees as compensation.

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The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
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-Section 45
-Paragraph 28
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- Definition

The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

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The risk-free interest rate assumption that is used in valuing an option on its own shares.

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Expected term of share-based compensation awards, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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-Publisher FASB
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