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Income Taxes - Reconciliation of U.S. Statutory Income Tax Rate to Effective Tax Rate (Details 4)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate      
Federal income tax at statutory rate (as a percent) 34.00% 34.00% 34.00%
State income tax benefit, net of federal benefit (as a percent) 6.00% 6.00% 5.70%
Research and development tax credits (as a percent) 2.00% 3.00% 2.70%
Other (as a percent) (2.00%)   (1.40%)
Increase to valuation allowance (as a percent) (24.00%) (24.00%) (41.00%)
Effective income tax rate (as a percent) 16.00% 19.00% 0.00%