<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001258693</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001649094</issuerCik>
      <issuerName>Vaxcyte, Inc.</issuerName>
      <secFileNumber>001-39323</secFileNumber>
      <issuerAddress>
        <com:street1>825 INDUSTRIAL ROAD, STE. 300</com:street1>
        <com:city>SAN CARLOS</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>94070</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>650-837-0111</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PICKERING GRANT</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>UBS Financial Services, Inc.</name>
        <address>
          <com:street1>1000 Harbor Boulevard</com:street1>
          <com:city>Weehawken</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07016</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2366</noOfUnitsSold>
      <aggregateMarketValue>221646.88</aggregateMarketValue>
      <noOfUnitsOutstanding>124636546</noOfUnitsOutstanding>
      <approxSaleDate>12/09/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/09/2013</acquiredDate>
      <natureOfAcquisitionTransaction>Founders shares</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2366</amountOfSecuritiesAcquired>
      <paymentDate>12/09/2013</paymentDate>
      <natureOfPayment>NA</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Grant Pickering</name>
        <address>
          <com:street1>c/o 825 Industrial Road</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>San Carlos</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/01/2024</saleDate>
      <amountOfSecuritiesSold>55000</amountOfSecuritiesSold>
      <grossProceeds>6283853.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Benjamin Pickering 2020 Delaware Trust</name>
        <address>
          <com:street1>c/o 825 Industrial Road</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>San Carlos</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/07/2024</saleDate>
      <amountOfSecuritiesSold>3549</amountOfSecuritiesSold>
      <grossProceeds>387613.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Claire Pickering 2020 Delaware Trust</name>
        <address>
          <com:street1>c/o 825 Industrial Road</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>San Carlos</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/07/2024</saleDate>
      <amountOfSecuritiesSold>3549</amountOfSecuritiesSold>
      <grossProceeds>387542.76</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Grant Pickering</name>
        <address>
          <com:street1>c/o 825 Industrial Road</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>San Carlos</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>11/01/2024</saleDate>
      <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
      <grossProceeds>1602256.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Benjamin Pickering 2020 Delaware Trust</name>
        <address>
          <com:street1>c/o 825 Industrial Road</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>San Carlos</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>11/07/2024</saleDate>
      <amountOfSecuritiesSold>1183</amountOfSecuritiesSold>
      <grossProceeds>122884.48</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Claire Pickering 2020 Delaware Trust</name>
        <address>
          <com:street1>c/o 825 Industrial Road</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>San Carlos</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>11/07/2024</saleDate>
      <amountOfSecuritiesSold>1183</amountOfSecuritiesSold>
      <grossProceeds>122911.69</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Grant Pickering</name>
        <address>
          <com:street1>c/o 825 Industrial Road</com:street1>
          <com:street2>Suite 300</com:street2>
          <com:city>San Carlos</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94070</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/02/2024</saleDate>
      <amountOfSecuritiesSold>15000</amountOfSecuritiesSold>
      <grossProceeds>1386790.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>1,183 shares represented in this filing are being sold under The Claire Pickering 2020 Delaware Trust and 1,183 shares are being sold under the Benjamin Pickering 2020 Delaware Trust.</remarks>
    <noticeSignature>
      <noticeDate>12/09/2024</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>04/12/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ UBS Financial Services Inc, as attorney-in-fact for The Goldman Sachs Trust Company of Delaware Trustee</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
