144 0001258693 XXXXXXXX LIVE 0001649094 Vaxcyte, Inc. 001-39323 825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070 650-837-0111 PICKERING GRANT Officer Director Common UBS Financial Services, Inc.

11 Madison Ave 4th Floor New York NY 10010

24237 1303223.49 144397682 06/26/2026 NASDAQ Common 03/02/2025 RSU Vest Issuer N 2410 03/02/2025 NA Common 12/09/2013 Founder Shares Issuer N 2000 12/09/2013 NA Common 03/02/2024 RSU Vest Issuer N 7752 03/02/2024 N/A Common 09/02/2023 RSU Vest Issuer N 12075 09/02/2023 N/A N Grant Pickering

825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070

Common 06/18/2026 22461 1179204.75 The Claire Pickering 2020 Delaware Trust

825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070

Common 06/18/2026 1000 52500.00 The Benjamin Pickering 2020 Delaware Trust

825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070

Common 06/18/2026 1000 52500.00 22,237 shares represented in this filing are being sold under Grant Pickering, 1,000 shares are being sold under the Claire Pickering 2020 Delaware Trust and 1,000 shares are being sold under the Benjamin Pickering 2020Delaware Trust. 06/26/2026 03/03/2026 /s/ UBS Financial Services Inc, as attorney-in-fact for Grant Pickering