144 0001258693 XXXXXXXX LIVE 0001649094 Vaxcyte, Inc. 001-39323 825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070 650-837-0111 PICKERING GRANT Officer Common UBS Financial Services, Inc.

1000 Harbor Boulevard Weehawken NJ 07016

24461 1284204.75 144397682 06/18/2026 NASDAQ Common 06/18/2026 Exercise of stock options Issuer N 225 06/18/2026 Cash Common 09/02/2024 RSU Vest Issuer N 7751 09/02/2024 NA Common 08/31/2024 RSU Vest Issuer N 5548 08/31/2024 NA Common 02/28/2025 RSU Vest Issuer N 3612 02/28/2025 NA Common 03/02/2025 RSU Vest Issuer N 5325 03/02/2025 NA Common 12/09/2013 Founder Shares Issuer N 2000 12/09/2013 NA Y 22,461 shares represented in this filing are being sold under Grant Pickering, 1,000 shares are being sold under the Claire Pickering 2020 Delaware Trust and 1,000 shares are being sold under the Benjamin Pickering 2020Delaware Trust. 06/18/2026 03/03/2026 /s/ UBS Financial Services Inc, as attorney-in-fact for Grant Pickering