X0306 4 2014-04-15 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001256126 MUELLER PETER C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Global R&D, CSO Common Stock 2014-04-15 4 M 0 1750 28.84 A 160500 D Common Stock 2014-04-15 4 M 0 5750 32.16 A 166250 D Common Stock 2014-04-15 4 S 0 2100 60.57 D 164150 D Common Stock 2014-04-15 4 S 0 2900 61.53 D 161250 D Common Stock 2014-04-15 4 S 0 1800 62.38 D 159450 D Common Stock 2014-04-15 4 S 0 700 63.27 D 158750 D Common Stock 4770 I 401(k) Common Stock 5568 I Revocable Trust Stock Option (right to buy) 28.84 2014-04-15 4 M 0 1750 0.00 D 2017-07-11 Common Stock 1750 0 D Stock Option (righty to buy) 32.16 2014-04-15 4 M 0 5750 0.00 D 2018-07-23 Common Stock 5750 30500 D Transaction made pursuant to Dr. Mueller's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $60.57 (range $60.06 to $60.94). Dr. Mueller undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $61.53 (range $61.05 to $61.97). Open market sales reported on this line occurred at a weighted average price of $62.38 (range $62.00 to $62.84). Open market sales reported on this line occurred at a weighted average price of $63.27 (range $63.03 to $63.65). Fully vested. Kenneth L. Horton, Attorney-In-Fact 2014-04-17