<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2020-02-27</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001013934</issuerCik>
        <issuerName>Strategic Education, Inc.</issuerName>
        <issuerTradingSymbol>STRA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001256121</rptOwnerCik>
            <rptOwnerName>SILBERMAN ROBERT S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2303 DULLES STATION BLVD.</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>HERNDON</rptOwnerCity>
            <rptOwnerState>VA</rptOwnerState>
            <rptOwnerZipCode>20171</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Executive Chairman</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

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            <transactionAmounts>
                <transactionShares>
                    <value>100</value>
                    <footnoteId id="F3"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>148.86</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>146919</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-03-02</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>6182</value>
                    <footnoteId id="F3"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>145.09</value>
                    <footnoteId id="F23"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>140737</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-03-02</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>9212</value>
                    <footnoteId id="F3"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>145.99</value>
                    <footnoteId id="F24"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>131525</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-03-02</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>10063</value>
                    <footnoteId id="F3"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>146.93</value>
                    <footnoteId id="F25"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>121462</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-03-02</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>6650</value>
                    <footnoteId id="F3"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>147.76</value>
                    <footnoteId id="F26"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>114812</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-03-02</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>120</value>
                    <footnoteId id="F3"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>149.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>114692</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">These shares are restricted and will vest on February 27, 2024, subject to the satisfaction of certain performance criteria.</footnote>
        <footnote id="F2">Includes 851 shares acquired under the Company's 401(k) plan.</footnote>
        <footnote id="F3">Represents shares sold immediately following the delivery of previously deferred shares which were settled upon the effective date of action taken by the Board of Directors to terminate deferred compensation arrangements.  The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 12, 2019.</footnote>
        <footnote id="F4">Weighted average shares, as these shares were sold in multiple transactions ranging from $142.76 to $143.74, inclusive.</footnote>
        <footnote id="F5">Weighted average shares, as these shares were sold in multiple transactions ranging from $143.85 to $144.77, inclusive.</footnote>
        <footnote id="F6">Weighted average shares, as these shares were sold in multiple transactions ranging from $144.91 to $145.90, inclusive.</footnote>
        <footnote id="F7">Weighted average shares, as these shares were sold in multiple transactions ranging from $145.99 to $146.98, inclusive.</footnote>
        <footnote id="F8">Weighted average shares, as these shares were sold in multiple transactions ranging from $146.99 to $147.95, inclusive.</footnote>
        <footnote id="F9">Weighted average shares, as these shares were sold in multiple transactions ranging from $147.99 to $148.98, inclusive.</footnote>
        <footnote id="F10">Weighted average shares, as these shares were sold in multiple transactions ranging from $148.99 to $149.83, inclusive.</footnote>
        <footnote id="F11">Weighted average shares, as these shares were sold in multiple transactions ranging from $150.01 to $150.92, inclusive.</footnote>
        <footnote id="F12">Weighted average shares, as these shares were sold in multiple transactions ranging from $151.04 to $152.03, inclusive.</footnote>
        <footnote id="F13">Weighted average shares, as these shares were sold in multiple transactions ranging from $152.04 to $152.13, inclusive.</footnote>
        <footnote id="F14">Weighted average shares, as these shares were sold in multiple transactions ranging from $137.93 to $138.58, inclusive.</footnote>
        <footnote id="F15">Weighted average shares, as these shares were sold in multiple transactions ranging from $139.75 to $140.68, inclusive.</footnote>
        <footnote id="F16">Weighted average shares, as these shares were sold in multiple transactions ranging from $140.77 to $141.63, inclusive.</footnote>
        <footnote id="F17">Weighted average shares, as these shares were sold in multiple transactions ranging from $142.12 to $142.88, inclusive.</footnote>
        <footnote id="F18">Weighted average shares, as these shares were sold in multiple transactions ranging from $143.14 to $144.11, inclusive.</footnote>
        <footnote id="F19">Weighted average shares, as these shares were sold in multiple transactions ranging from $144.52 to $144.88, inclusive.</footnote>
        <footnote id="F20">Weighted average shares, as these shares were sold in multiple transactions ranging from $145.76 to $146.75, inclusive.</footnote>
        <footnote id="F21">Weighted average shares, as these shares were sold in multiple transactions ranging from $146.83 to $147.80, inclusive.</footnote>
        <footnote id="F22">Weighted average shares, as these shares were sold in multiple transactions ranging from $147.83 to $148.81, inclusive.</footnote>
        <footnote id="F23">Weighted average shares, as these shares were sold in multiple transactions ranging from $144.44 to $145.43, inclusive.</footnote>
        <footnote id="F24">Weighted average shares, as these shares were sold in multiple transactions ranging from $145.44 to $146.43, inclusive.</footnote>
        <footnote id="F25">Weighted average shares, as these shares were sold in multiple transactions ranging from $146.44 to $147.42, inclusive.</footnote>
        <footnote id="F26">Weighted average shares, as these shares were sold in multiple transactions ranging from $147.46 to $148.29, inclusive. The reporting person undertakes to provide Strategic Education, Inc., any security holder of Strategic Education, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Daniel W. Jackson, Attorney-in-Fact</signatureName>
        <signatureDate>2020-03-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
