The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
908 DEVICES INC COM 65443P102 3,283 100,961 SH   SOLE   100,961 0 0
ABSCI CORPORATION COM 00091E109 3,344 287,560 SH   SOLE   287,560 0 0
AC IMMUNE SA SHS H00263105 7,129 1,062,462 SH   SOLE   1,062,462 0 0
ACCELERON PHARMA INC COM 00434H108 2,387 13,872 SH   SOLE   13,872 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 2,784 81,894 SH   SOLE   81,894 0 0
ALBIREO PHARMA INC COM 01345P106 7,656 245,381 SH   SOLE   245,381 0 0
ALECTOR INC COM 014442107 1,492 65,380 SH   SOLE   65,380 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 161,174 1,088,648 SH   SOLE   962,813 0 125,835
ALKERMES PLC SHS G01767105 2,473 80,185 SH   SOLE   80,185 0 0
ALLY FINL INC COM 02005N100 32,936 645,162 SH   SOLE   645,162 0 0
ALPHA TEKNOVA INC COM 02080L102 3,734 150,000 SH   SOLE   150,000 0 0
ALPHABET INC CAP STK CL A 02079K305 30,069 11,247 SH   SOLE   11,247 0 0
ALPHABET INC CAP STK CL C 02079K107 63,112 23,679 SH   SOLE   23,679 0 0
AMBARELLA INC SHS G037AX101 287 1,842 SH   SOLE   1,842 0 0
AMERISOURCEBERGEN CORP COM 03073E105 87 726 SH   SOLE   726 0 0
AMGEN INC COM 031162100 86 403 SH   SOLE   403 0 0
ANALOG DEVICES INC COM 032654105 3,039 18,145 SH   SOLE   18,145 0 0
APPLE INC COM 037833100 1,810 12,788 SH   SOLE   12,788 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 1,352 28,300 SH   SOLE   28,300 0 0
ARCUS BIOSCIENCES INC COM 03969F109 2,154 61,780 SH   SOLE   61,780 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 1,579 886,867 SH   SOLE   886,867 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 5,752 1,653,009 SH   SOLE   1,653,009 0 0
AT&T INC COM 00206R102 127 4,694 SH   SOLE   4,694 0 0
ATRECA INC CL A COM 04965G109 2,483 398,541 SH   SOLE   398,541 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 2,327 94,496 SH   SOLE   94,496 0 0
AZIYO BIOLOGICS INC COM CL A 05479K106 1,362 195,809 SH   SOLE   195,809 0 0
BARRICK GOLD CORP COM 067901108 128,839 7,137,871 SH   SOLE   5,676,094 0 1,461,777
BIO RAD LABS INC CL A 090572207 4,837 6,485 SH   SOLE   6,485 0 0
BIOATLA INC COM 09077B104 1,668 56,642 SH   SOLE   56,642 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 1,864 129,688 SH   SOLE   129,688 0 0
BIONTECH SE SPONSORED ADS 09075V102 2,045 7,492 SH   SOLE   7,492 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,788 27,121 SH   SOLE   27,121 0 0
BOOKING HOLDINGS INC COM 09857L108 88,678 37,356 SH   SOLE   30,218 0 7,138
BTRS HOLDINGS INC COM CL 1 11778X104 21,619 2,031,892 SH   SOLE   2,031,892 0 0
CABOT OIL & GAS CORP COM 127097103 197 9,049 SH   SOLE   9,049 0 0
CAMPBELL SOUP CO COM 134429109 85 2,043 SH   SOLE   2,043 0 0
CARVANA CO CL A 146869102 2,508 8,316 SH   SOLE   8,316 0 0
CENTOGENE N V COM N1976T109 21,173 1,923,085 SH   SOLE   1,923,085 0 0
CIENA CORP COM NEW 171779309 69,442 1,352,330 SH   SOLE   1,223,502 0 128,828
CIGNA CORP NEW COM 125523100 84 418 SH   SOLE   418 0 0
CISCO SYS INC COM 17275R102 1,943 35,700 SH   SOLE   35,700 0 0
CLEVELAND-CLIFFS INC NEW COM 185899101 4,799 242,246 SH   SOLE   242,246 0 0
COGENT BIOSCIENCES INC COM 19240Q201 8,261 982,298 SH   SOLE   957,465 0 24,833
COGNYTE SOFTWARE LTD ORD SHS M25133105 586 28,506 SH   SOLE   28,506 0 0
COHERUS BIOSCIENCES INC COM 19249H103 9,248 575,510 SH   SOLE   575,510 0 0
CREDICORP LTD COM G2519Y108 47 424 SH   SOLE   424 0 0
CVS HEALTH CORP COM 126650100 128 1,509 SH   SOLE   1,509 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 5,488 1,078,103 SH   SOLE   1,078,103 0 0
DENALI THERAPEUTICS INC COM 24823R105 1,553 30,791 SH   SOLE   30,791 0 0
DISH NETWORK CORPORATION CL A 25470M109 289 6,644 SH   SOLE   6,644 0 0
EBAY INC. COM 278642103 1,580 22,679 SH   SOLE   22,679 0 0
EPIZYME INC COM 29428V104 9,748 1,903,893 SH   SOLE   1,903,893 0 0
EQUIFAX INC COM 294429105 47,267 186,515 SH   SOLE   186,515 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 20,644 1,713,176 SH   SOLE   1,534,060 0 179,116
EXAGEN INC COM 30068X103 5,440 400,000 SH   SOLE   344,533 0 55,467
F45 TRAINING HLDGS INC COM 30322L101 8,228 550,000 SH   SOLE   550,000 0 0
FACEBOOK INC CL A 30303M102 71,610 210,996 SH   SOLE   210,996 0 0
FEDEX CORP COM 31428X106 20,674 94,276 SH   SOLE   94,276 0 0
FOX CORP CL A COM 35137L105 45 1,120 SH   SOLE   1,120 0 0
FREEPORT-MCMORAN INC CL B 35671D857 40,464 1,243,887 SH   SOLE   1,023,593 0 220,294
FS DEVELOPMENT CORP II COM CL A 30318F100 9,611 965,950 SH   SOLE   965,950 0 0
FULCRUM THERAPEUTICS INC COM 359616109 4,293 152,186 SH   SOLE   152,186 0 0
FULL TRUCK ALLIANCE CO LTD SPONSORED ADS 35969L108 2,176 141,924 SH   SOLE   141,924 0 0
GENERAL ELECTRIC CO COM NEW 369604301 96,855 940,067 SH   SOLE   690,121 0 249,946
GENETRON HLDGS LTD ADS 37186H100 17,227 1,243,816 SH   SOLE   1,243,816 0 0
GILEAD SCIENCES INC COM 375558103 101,892 1,458,730 SH   SOLE   1,201,991 0 256,739
HCA HEALTHCARE INC COM 40412C101 88 362 SH   SOLE   362 0 0
HELLO GROUP INC ADS 423403104 75 7,129 SH   SOLE   7,129 0 0
HERBALIFE NUTRITION LTD COM SHS G4412G101 87 2,048 SH   SOLE   2,048 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 69,683 1,519,462 SH   SOLE   1,519,462 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 5,786 158,054 SH   SOLE   158,054 0 0
ICOSAVAX INC COM 45114M109 23,275 786,575 SH   SOLE   744,851 0 41,724
IDEAYA BIOSCIENCES INC COM 45166A102 29,364 1,151,998 SH   SOLE   1,047,063 0 104,935
IHS MARKIT LTD SHS G47567105 1,672 14,338 SH   SOLE   14,338 0 0
IMMATICS N.V SHS N44445109 4,321 332,356 SH   SOLE   332,356 0 0
IMMUNOVANT INC COM 45258J102 4,824 555,065 SH   SOLE   555,065 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,866 545,508 SH   SOLE   545,508 0 0
INHIBRX INC COM 45720L107 3,450 103,583 SH   SOLE   103,583 0 0
INOVALON HLDGS INC COM CL A 45781D101 355 8,800 SH   SOLE   8,800 0 0
INTEL CORP COM 458140100 839 15,750 SH   SOLE   15,750 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 86,203 750,770 SH   SOLE   681,926 0 68,844
INTERNATIONAL BUSINESS MACHS COM 459200101 179 1,285 SH   SOLE   1,285 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 36 6,912 SH   SOLE   6,912 0 0
JD.COM INC SPON ADR CL A 47215P106 37,727 522,239 SH   SOLE   522,239 0 0
JUST EAT TAKEAWAY COM N V SPONSORED ADS 48214T305 4,638 319,228 SH   SOLE   319,228 0 0
LAM RESEARCH CORP COM 512807108 76,238 133,951 SH   SOLE   119,555 0 14,396
LEAP THERAPEUTICS INC COM 52187K101 5,325 1,327,952 SH   SOLE   1,327,952 0 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 441 14,800 SH   SOLE   14,800 0 0
LOGICBIO THERAPEUTICS INC COM 54142F102 1,467 320,273 SH   SOLE   320,273 0 0
LOUISIANA PAC CORP COM 546347105 83,428 1,359,426 SH   SOLE   1,136,586 0 222,840
LUMEN TECHNOLOGIES INC COM 550241103 755 60,907 SH   SOLE   60,907 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 6,269 66,802 SH   SOLE   66,802 0 0
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 76 1,669 SH   SOLE   1,669 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 2,335 320,698 SH   SOLE   320,698 0 0
MEDALLIA INC COM 584021109 3,702 109,307 SH   SOLE   109,307 0 0
MELCO RESORTS AND ENTMNT LTD ADR 585464100 21,159 2,066,285 SH   SOLE   2,066,285 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,046 110,906 SH   SOLE   110,906 0 0
MERUS N V COM N5749R100 5,281 240,037 SH   SOLE   240,037 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 301,756 1,965,968 SH   SOLE   1,753,232 0 212,736
MICRON TECHNOLOGY INC COM 595112103 248,755 3,504,582 SH   SOLE   3,112,762 0 391,820
MICROSOFT CORP COM 594918104 8,015 28,431 SH   SOLE   28,431 0 0
MOSAIC CO NEW COM 61945C103 137,140 3,839,303 SH   SOLE   3,459,433 0 379,870
MOTOROLA SOLUTIONS INC COM NEW 620076307 655 2,818 SH   SOLE   2,818 0 0
MYOVANT SCIENCES LTD COM G637AM102 4,381 195,211 SH   SOLE   195,211 0 0
MYT NETHERLANDS PARENT B V ADS 55406W103 541 20,118 SH   SOLE   20,118 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 13,475 280,671 SH   SOLE   249,552 0 31,119
NIELSEN HLDGS PLC SHS EUR G6518L108 326 17,000 SH   SOLE   17,000 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102 65,532 1,764,939 SH   SOLE   1,764,939 0 0
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105 9,425 500,000 SH   SOLE   473,199 0 26,801
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 4,103 1,000,847 SH   SOLE   1,000,847 0 0
ORACLE CORP COM 68389X105 2,197 25,213 SH   SOLE   25,213 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 2,480 1,078,315 SH   SOLE   1,078,315 0 0
OVID THERAPEUTICS INC COM 690469101 2,577 766,901 SH   SOLE   766,901 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 6,675 261,242 SH   SOLE   238,791 0 22,451
PAYPAL HLDGS INC COM 70450Y103 3,004 11,543 SH   SOLE   11,543 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 89 8,609 SH   SOLE   8,609 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 5,316 1,028,322 SH   SOLE   1,028,322 0 0
PLANET FITNESS INC CL A 72703H101 10,407 132,486 SH   SOLE   132,486 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 11,915 502,520 SH   SOLE   460,977 0 41,543
PROTHENA CORP PLC SHS G72800108 4,310 60,512 SH   SOLE   60,512 0 0
QUANTERIX CORP COM 74766Q101 25,616 514,488 SH   SOLE   468,515 0 45,973
RECURSION PHARMACEUTICALS IN CL A 75629V104 15,226 661,703 SH   SOLE   616,409 0 45,294
ROBLOX CORP CL A 771049103 6,297 83,344 SH   SOLE   83,344 0 0
SANGAMO THERAPEUTICS INC COM 800677106 1,967 218,336 SH   SOLE   218,336 0 0
SILVERCREST METALS INC COM 828363101 19,575 2,804,448 SH   SOLE   2,089,651 0 714,797
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 1,200 107,223 SH   SOLE   107,223 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 65,725 398,864 SH   SOLE   316,334 0 82,530
SPROUTS FMRS MKT INC COM 85208M102 41 1,782 SH   SOLE   1,782 0 0
SQUARE INC CL A 852234103 12,813 53,422 SH   SOLE   53,422 0 0
SUZANO S A SPON ADS 86959K105 12,413 1,241,314 SH   SOLE   1,241,314 0 0
SYNEOS HEALTH INC CL A 87166B102 7,072 80,841 SH   SOLE   80,841 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 14,826 3,063,279 SH   SOLE   3,063,279 0 0
TRIP COM GROUP LTD ADS 89677Q107 319,009 10,374,270 SH   SOLE   9,352,667 0 1,021,603
TWILIO INC CL A 90138F102 474 1,486 SH   SOLE   1,486 0 0
ULTA BEAUTY INC COM 90384S303 12,040 33,358 SH   SOLE   33,358 0 0
UNITED STATES STL CORP NEW COM 912909108 3,001 136,600 SH   SOLE   136,600 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 80 575 SH   SOLE   575 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 85 471 SH   SOLE   471 0 0
WARRIOR MET COAL INC COM 93627C101 18,507 795,295 SH   SOLE   661,995 0 133,300
WAVE LIFE SCIENCES LTD SHS Y95308105 3,803 776,121 SH   SOLE   776,121 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 3,662 213,381 SH   SOLE   213,381 0 0
XILINX INC COM 983919101 1,390 9,209 SH   SOLE   9,209 0 0
YUM CHINA HLDGS INC COM 98850P109 6,344 109,179 SH   SOLE   109,179 0 0
ZAI LAB LTD ADR 98887Q104 4,023 38,170 SH   SOLE   38,170 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 486,456 15,866,154 SH   SOLE   14,203,527 0 1,662,627
ZYMEWORKS INC COM 98985W102 4,513 155,412 SH   SOLE   155,412 0 0