The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
908 DEVICES INCCOM65443P1023,283100,961SH SOLE 100,96100
ABSCI CORPORATIONCOM00091E1093,344287,560SH SOLE 287,56000
AC IMMUNE SASHSH002631057,1291,062,462SH SOLE 1,062,46200
ACCELERON PHARMA INCCOM00434H1082,38713,872SH SOLE 13,87200
ADAPTIVE BIOTECHNOLOGIES CORCOM00650F1092,78481,894SH SOLE 81,89400
ALBIREO PHARMA INCCOM01345P1067,656245,381SH SOLE 245,38100
ALECTOR INCCOM0144421071,49265,380SH SOLE 65,38000
ALIBABA GROUP HLDG LTDSPONSORED ADS01609W102161,1741,088,648SH SOLE 962,8130125,835
ALKERMES PLCSHSG017671052,47380,185SH SOLE 80,18500
ALLY FINL INCCOM02005N10032,936645,162SH SOLE 645,16200
ALPHA TEKNOVA INCCOM02080L1023,734150,000SH SOLE 150,00000
ALPHABET INCCAP STK CL A02079K30530,06911,247SH SOLE 11,24700
ALPHABET INCCAP STK CL C02079K10763,11223,679SH SOLE 23,67900
AMBARELLA INCSHSG037AX1012871,842SH SOLE 1,84200
AMERISOURCEBERGEN CORPCOM03073E10587726SH SOLE 72600
AMGEN INCCOM03116210086403SH SOLE 40300
ANALOG DEVICES INCCOM0326541053,03918,145SH SOLE 18,14500
APPLE INCCOM0378331001,81012,788SH SOLE 12,78800
ARCTURUS THERAPEUTICS HLDGSCOM03969T1091,35228,300SH SOLE 28,30000
ARCUS BIOSCIENCES INCCOM03969F1092,15461,780SH SOLE 61,78000
ASLAN PHARMACEUTICALS LTDADS04522R1011,579886,867SH SOLE 886,86700
ASSEMBLY BIOSCIENCES INCCOM0453961085,7521,653,009SH SOLE 1,653,00900
AT&T INCCOM00206R1021274,694SH SOLE 4,69400
ATRECA INCCL A COM04965G1092,483398,541SH SOLE 398,54100
AVIDITY BIOSCIENCES INCCOM05370A1082,32794,496SH SOLE 94,49600
AZIYO BIOLOGICS INCCOM CL A05479K1061,362195,809SH SOLE 195,80900
BARRICK GOLD CORPCOM067901108128,8397,137,871SH SOLE 5,676,09401,461,777
BIO RAD LABS INCCL A0905722074,8376,485SH SOLE 6,48500
BIOATLA INCCOM09077B1041,66856,642SH SOLE 56,64200
BIOCRYST PHARMACEUTICALS INCCOM09058V1031,864129,688SH SOLE 129,68800
BIONTECH SESPONSORED ADS09075V1022,0457,492SH SOLE 7,49200
BLUEPRINT MEDICINES CORPCOM09627Y1092,78827,121SH SOLE 27,12100
BOOKING HOLDINGS INCCOM09857L10888,67837,356SH SOLE 30,21807,138
BTRS HOLDINGS INCCOM CL 111778X10421,6192,031,892SH SOLE 2,031,89200
CABOT OIL & GAS CORPCOM1270971031979,049SH SOLE 9,04900
CAMPBELL SOUP COCOM134429109852,043SH SOLE 2,04300
CARVANA COCL A1468691022,5088,316SH SOLE 8,31600
CENTOGENE N VCOMN1976T10921,1731,923,085SH SOLE 1,923,08500
CIENA CORPCOM NEW17177930969,4421,352,330SH SOLE 1,223,5020128,828
CIGNA CORP NEWCOM12552310084418SH SOLE 41800
CISCO SYS INCCOM17275R1021,94335,700SH SOLE 35,70000
CLEVELAND-CLIFFS INC NEWCOM1858991014,799242,246SH SOLE 242,24600
COGENT BIOSCIENCES INCCOM19240Q2018,261982,298SH SOLE 957,465024,833
COGNYTE SOFTWARE LTDORD SHSM2513310558628,506SH SOLE 28,50600
COHERUS BIOSCIENCES INCCOM19249H1039,248575,510SH SOLE 575,51000
CREDICORP LTDCOMG2519Y10847424SH SOLE 42400
CVS HEALTH CORPCOM1266501001281,509SH SOLE 1,50900
CYTOMX THERAPEUTICS INCCOM23284F1055,4881,078,103SH SOLE 1,078,10300
DENALI THERAPEUTICS INCCOM24823R1051,55330,791SH SOLE 30,79100
DISH NETWORK CORPORATIONCL A25470M1092896,644SH SOLE 6,64400
EBAY INC.COM2786421031,58022,679SH SOLE 22,67900
EPIZYME INCCOM29428V1049,7481,903,893SH SOLE 1,903,89300
EQUIFAX INCCOM29442910547,267186,515SH SOLE 186,51500
ESPERION THERAPEUTICS INC NECOM29664W10520,6441,713,176SH SOLE 1,534,0600179,116
EXAGEN INCCOM30068X1035,440400,000SH SOLE 344,533055,467
F45 TRAINING HLDGS INCCOM30322L1018,228550,000SH SOLE 550,00000
FACEBOOK INCCL A30303M10271,610210,996SH SOLE 210,99600
FEDEX CORPCOM31428X10620,67494,276SH SOLE 94,27600
FOX CORPCL A COM35137L105451,120SH SOLE 1,12000
FREEPORT-MCMORAN INCCL B35671D85740,4641,243,887SH SOLE 1,023,5930220,294
FS DEVELOPMENT CORP IICOM CL A30318F1009,611965,950SH SOLE 965,95000
FULCRUM THERAPEUTICS INCCOM3596161094,293152,186SH SOLE 152,18600
FULL TRUCK ALLIANCE CO LTDSPONSORED ADS35969L1082,176141,924SH SOLE 141,92400
GENERAL ELECTRIC COCOM NEW36960430196,855940,067SH SOLE 690,1210249,946
GENETRON HLDGS LTDADS37186H10017,2271,243,816SH SOLE 1,243,81600
GILEAD SCIENCES INCCOM375558103101,8921,458,730SH SOLE 1,201,9910256,739
HCA HEALTHCARE INCCOM40412C10188362SH SOLE 36200
HELLO GROUP INCADS423403104757,129SH SOLE 7,12900
HERBALIFE NUTRITION LTDCOM SHSG4412G101872,048SH SOLE 2,04800
HUAZHU GROUP LTDSPONSORED ADS44332N10669,6831,519,462SH SOLE 1,519,46200
HUTCHMED CHINA LTDSPONSORED ADS44842L1035,786158,054SH SOLE 158,05400
ICOSAVAX INCCOM45114M10923,275786,575SH SOLE 744,851041,724
IDEAYA BIOSCIENCES INCCOM45166A10229,3641,151,998SH SOLE 1,047,0630104,935
IHS MARKIT LTDSHSG475671051,67214,338SH SOLE 14,33800
IMMATICS N.VSHSN444451094,321332,356SH SOLE 332,35600
IMMUNOVANT INCCOM45258J1024,824555,065SH SOLE 555,06500
INFINITY PHARMACEUTICALS INCCOM45665G3031,866545,508SH SOLE 545,50800
INHIBRX INCCOM45720L1073,450103,583SH SOLE 103,58300
INOVALON HLDGS INCCOM CL A45781D1013558,800SH SOLE 8,80000
INTEL CORPCOM45814010083915,750SH SOLE 15,75000
INTERCONTINENTAL EXCHANGE INCOM45866F10486,203750,770SH SOLE 681,926068,844
INTERNATIONAL BUSINESS MACHSCOM4592001011791,285SH SOLE 1,28500
ITAU UNIBANCO HLDG S ASPON ADR REP PFD465562106366,912SH SOLE 6,91200
JD.COM INCSPON ADR CL A47215P10637,727522,239SH SOLE 522,23900
JUST EAT TAKEAWAY COM N VSPONSORED ADS48214T3054,638319,228SH SOLE 319,22800
LAM RESEARCH CORPCOM51280710876,238133,951SH SOLE 119,555014,396
LEAP THERAPEUTICS INCCOM52187K1015,3251,327,952SH SOLE 1,327,95200
LIBERTY GLOBAL PLCSHS CL AG5480U10444114,800SH SOLE 14,80000
LOGICBIO THERAPEUTICS INCCOM54142F1021,467320,273SH SOLE 320,27300
LOUISIANA PAC CORPCOM54634710583,4281,359,426SH SOLE 1,136,5860222,840
LUMEN TECHNOLOGIES INCCOM55024110375560,907SH SOLE 60,90700
LYONDELLBASELL INDUSTRIES NSHS - A -N537451006,26966,802SH SOLE 66,80200
MAGELLAN MIDSTREAM PRTNRS LPCOM UNIT RP LP559080106761,669SH SOLE 1,66900
MAGENTA THERAPEUTICS INCCOM55910K1082,335320,698SH SOLE 320,69800
MEDALLIA INCCOM5840211093,702109,307SH SOLE 109,30700
MELCO RESORTS AND ENTMNT LTDADR58546410021,1592,066,285SH SOLE 2,066,28500
MERSANA THERAPEUTICS INCCOM59045L1061,046110,906SH SOLE 110,90600
MERUS N VCOMN5749R1005,281240,037SH SOLE 240,03700
MICROCHIP TECHNOLOGY INC.COM595017104301,7561,965,968SH SOLE 1,753,2320212,736
MICRON TECHNOLOGY INCCOM595112103248,7553,504,582SH SOLE 3,112,7620391,820
MICROSOFT CORPCOM5949181048,01528,431SH SOLE 28,43100
MOSAIC CO NEWCOM61945C103137,1403,839,303SH SOLE 3,459,4330379,870
MOTOROLA SOLUTIONS INCCOM NEW6200763076552,818SH SOLE 2,81800
MYOVANT SCIENCES LTDCOMG637AM1024,381195,211SH SOLE 195,21100
MYT NETHERLANDS PARENT B VADS55406W10354120,118SH SOLE 20,11800
NANOSTRING TECHNOLOGIES INCCOM63009R10913,475280,671SH SOLE 249,552031,119
NIELSEN HLDGS PLCSHS EURG6518L10832617,000SH SOLE 17,00000
NOAH HLDGS LTDSPON ADS CL A65487X10265,5321,764,939SH SOLE 1,764,93900
OMEGA THERAPEUTICS INCCOMMON STOCK68217N1059,425500,000SH SOLE 473,199026,801
ONECONNECT FINL TECHNOLOGY CSPONSORED ADS68248T1054,1031,000,847SH SOLE 1,000,84700
ORACLE CORPCOM68389X1052,19725,213SH SOLE 25,21300
ORCHARD THERAPEUTICS PLCADS68570P1012,4801,078,315SH SOLE 1,078,31500
OVID THERAPEUTICS INCCOM6904691012,577766,901SH SOLE 766,90100
PACIFIC BIOSCIENCES CALIF INCOM69404D1086,675261,242SH SOLE 238,791022,451
PAYPAL HLDGS INCCOM70450Y1033,00411,543SH SOLE 11,54300
PETROLEO BRASILEIRO SA PETROSPONSORED ADR71654V408898,609SH SOLE 8,60900
PIERIS PHARMACEUTICALS INCCOM7207951035,3161,028,322SH SOLE 1,028,32200
PLANET FITNESS INCCL A72703H10110,407132,486SH SOLE 132,48600
PROMETHEUS BIOSCIENCES INCCOM74349U10811,915502,520SH SOLE 460,977041,543
PROTHENA CORP PLCSHSG728001084,31060,512SH SOLE 60,51200
QUANTERIX CORPCOM74766Q10125,616514,488SH SOLE 468,515045,973
RECURSION PHARMACEUTICALS INCL A75629V10415,226661,703SH SOLE 616,409045,294
ROBLOX CORPCL A7710491036,29783,344SH SOLE 83,34400
SANGAMO THERAPEUTICS INCCOM8006771061,967218,336SH SOLE 218,33600
SILVERCREST METALS INCCOM82836310119,5752,804,448SH SOLE 2,089,6510714,797
SINGULAR GENOMICS SYSTEMS INCOM82933R1001,200107,223SH SOLE 107,22300
SKYWORKS SOLUTIONS INCCOM83088M10265,725398,864SH SOLE 316,334082,530
SPROUTS FMRS MKT INCCOM85208M102411,782SH SOLE 1,78200
SQUARE INCCL A85223410312,81353,422SH SOLE 53,42200
SUZANO S ASPON ADS86959K10512,4131,241,314SH SOLE 1,241,31400
SYNEOS HEALTH INCCL A87166B1027,07280,841SH SOLE 80,84100
TAL EDUCATION GROUPSPONSORED ADS87408010414,8263,063,279SH SOLE 3,063,27900
TRIP COM GROUP LTDADS89677Q107319,00910,374,270SH SOLE 9,352,66701,021,603
TWILIO INCCL A90138F1024741,486SH SOLE 1,48600
ULTA BEAUTY INCCOM90384S30312,04033,358SH SOLE 33,35800
UNITED STATES STL CORP NEWCOM9129091083,001136,600SH SOLE 136,60000
UNIVERSAL HLTH SVCS INCCL B91390310080575SH SOLE 57500
VERTEX PHARMACEUTICALS INCCOM92532F10085471SH SOLE 47100
WARRIOR MET COAL INCCOM93627C10118,507795,295SH SOLE 661,9950133,300
WAVE LIFE SCIENCES LTDSHSY953081053,803776,121SH SOLE 776,12100
WEREWOLF THERAPEUTICS INCCOM95075A1073,662213,381SH SOLE 213,38100
XILINX INCCOM9839191011,3909,209SH SOLE 9,20900
YUM CHINA HLDGS INCCOM98850P1096,344109,179SH SOLE 109,17900
ZAI LAB LTDADR98887Q1044,02338,170SH SOLE 38,17000
ZTO EXPRESS CAYMAN INCSPONSORED ADS A98980A105486,45615,866,154SH SOLE 14,203,52701,662,627
ZYMEWORKS INCCOM98985W1024,513155,412SH SOLE 155,41200