The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
908 DEVICES INC COM 65443P102 1,905 49,160 SH   SOLE   49,160 0 0
AC IMMUNE SA SHS H00263105 3,390 427,536 SH   SOLE   427,536 0 0
ACCELERON PHARMA INC COM 00434H108 1,741 13,872 SH   SOLE   13,872 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 2,406 58,890 SH   SOLE   58,890 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 3,119 56,593 SH   SOLE   56,593 0 0
ALBIREO PHARMA INC COM 01345P106 7,243 205,892 SH   SOLE   205,892 0 0
ALECTOR INC COM 014442107 1,664 79,884 SH   SOLE   79,884 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 89,462 394,490 SH   SOLE   394,490 0 0
ALKERMES PLC SHS G01767105 4,465 182,086 SH   SOLE   182,086 0 0
ALLY FINL INC COM 02005N100 202,382 4,060,631 SH   SOLE   3,749,269 0 311,362
ALPHA TEKNOVA INC COM 02080L102 3,560 150,000 SH   SOLE   150,000 0 0
ALPHABET INC CAP STK CL A 02079K305 39,359 16,119 SH   SOLE   16,119 0 0
ALPHABET INC CAP STK CL C 02079K107 58,924 23,510 SH   SOLE   23,510 0 0
AMBARELLA INC SHS G037AX101 360 3,374 SH   SOLE   3,374 0 0
AMERICAN EAGLE OUTFITTERS IN COM 02553E106 102,234 2,724,050 SH   SOLE   2,227,876 0 496,174
AMERISOURCEBERGEN CORP COM 03073E105 97 845 SH   SOLE   845 0 0
AMGEN INC COM 031162100 101 414 SH   SOLE   414 0 0
ANALOG DEVICES INC COM 032654105 5,214 30,284 SH   SOLE   30,284 0 0
APPLE INC COM 037833100 1,751 12,788 SH   SOLE   12,788 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 958 28,300 SH   SOLE   28,300 0 0
ARCUS BIOSCIENCES INC COM 03969F109 2,067 75,290 SH   SOLE   75,290 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 2,927 886,867 SH   SOLE   886,867 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 6,414 1,653,009 SH   SOLE   1,653,009 0 0
AT&T INC COM 00206R102 139 4,823 SH   SOLE   4,823 0 0
ATRECA INC CL A COM 04965G109 2,701 317,017 SH   SOLE   317,017 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 371 15,000 SH   SOLE   15,000 0 0
AZIYO BIOLOGICS INC COM CL A 05479K106 1,882 195,809 SH   SOLE   195,809 0 0
BARRICK GOLD CORP COM 067901108 197,699 9,559,921 SH   SOLE   8,074,471 0 1,485,450
BIO RAD LABS INC CL A 090572207 7,447 11,559 SH   SOLE   11,559 0 0
BIOATLA INC COM 09077B104 1,428 33,705 SH   SOLE   33,705 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 2,667 168,715 SH   SOLE   168,715 0 0
BIONTECH SE SPONSORED ADS 09075V102 13,894 62,059 SH   SOLE   62,059 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,386 27,121 SH   SOLE   27,121 0 0
BOOKING HOLDINGS INC COM 09857L108 86,727 39,636 SH   SOLE   32,363 0 7,273
CARVANA CO CL A 146869102 7,476 24,770 SH   SOLE   24,770 0 0
CENTOGENE N V COM N1976T109 17,379 1,664,672 SH   SOLE   1,664,672 0 0
CIENA CORP COM NEW 171779309 75,315 1,323,864 SH   SOLE   1,195,036 0 128,828
CISCO SYS INC COM 17275R102 1,892 35,700 SH   SOLE   35,700 0 0
CLEVELAND-CLIFFS INC NEW COM 185899101 4,136 191,837 SH   SOLE   191,837 0 0
COGENT BIOSCIENCES INC COM 19240Q201 6,700 826,119 SH   SOLE   801,286 0 24,833
COHERUS BIOSCIENCES INC COM 19249H103 7,959 575,510 SH   SOLE   575,510 0 0
CREDICORP LTD COM G2519Y108 52 431 SH   SOLE   431 0 0
CREDIT ACCEP CORP MICH COM 225310101 56 123 SH   SOLE   123 0 0
CUREVAC N V COM N2451R105 1,553 21,132 SH   SOLE   21,132 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 6,824 1,078,103 SH   SOLE   1,078,103 0 0
DENALI THERAPEUTICS INC COM 24823R105 2,415 30,791 SH   SOLE   30,791 0 0
DISH NETWORK CORPORATION CL A 25470M109 278 6,644 SH   SOLE   6,644 0 0
EBAY INC. COM 278642103 1,592 22,679 SH   SOLE   22,679 0 0
EQUIFAX INC COM 294429105 42,563 177,708 SH   SOLE   177,708 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 36,234 1,713,176 SH   SOLE   1,534,060 0 179,116
EXAGEN INC COM 30068X103 5,996 400,000 SH   SOLE   344,533 0 55,467
FACEBOOK INC CL A 30303M102 84,725 243,667 SH   SOLE   243,667 0 0
FEDEX CORP COM 31428X106 37,971 127,279 SH   SOLE   127,279 0 0
FOX CORP CL A COM 35137L105 48 1,302 SH   SOLE   1,302 0 0
FREEPORT-MCMORAN INC CL B 35671D857 46,342 1,248,773 SH   SOLE   1,028,479 0 220,294
FULCRUM THERAPEUTICS INC COM 359616109 1,595 152,186 SH   SOLE   152,186 0 0
GENERAL ELECTRIC CO COM 369604103 126,021 9,362,612 SH   SOLE   7,289,715 0 2,072,897
GENETRON HLDGS LTD ADS 37186H100 16,408 814,674 SH   SOLE   814,674 0 0
GILEAD SCIENCES INC COM 375558103 104,601 1,519,033 SH   SOLE   1,262,294 0 256,739
HANESBRANDS INC COM 410345102 101 5,416 SH   SOLE   5,416 0 0
HCA HEALTHCARE INC COM 40412C101 101 490 SH   SOLE   490 0 0
HERBALIFE NUTRITION LTD COM SHS G4412G101 104 1,979 SH   SOLE   1,979 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 94,605 1,791,425 SH   SOLE   1,791,425 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103 6,207 158,054 SH   SOLE   158,054 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 4,801 228,721 SH   SOLE   228,721 0 0
IHS MARKIT LTD SHS G47567105 2,192 19,460 SH   SOLE   19,460 0 0
IMMATICS N.V SHS N44445109 3,859 332,356 SH   SOLE   332,356 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,576 527,101 SH   SOLE   527,101 0 0
INHIBRX INC COM 45720L107 4,277 155,401 SH   SOLE   155,401 0 0
INOVALON HLDGS INC COM CL A 45781D101 300 8,800 SH   SOLE   8,800 0 0
INTEL CORP COM 458140100 914 16,274 SH   SOLE   16,274 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 3,426 21,157 SH   SOLE   21,157 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 88,313 743,999 SH   SOLE   675,155 0 68,844
INTERNATIONAL BUSINESS MACHS COM 459200101 219 1,494 SH   SOLE   1,494 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 48 8,033 SH   SOLE   8,033 0 0
JD.COM INC SPON ADR CL A 47215P106 44,706 560,151 SH   SOLE   560,151 0 0
JUST EAT TAKEAWAY COM N V SPONSORED ADS 48214T305 7,183 393,363 SH   SOLE   393,363 0 0
KIMBERLY-CLARK CORP COM 494368103 104 780 SH   SOLE   780 0 0
LAM RESEARCH CORP COM 512807108 87,406 134,326 SH   SOLE   119,930 0 14,396
LEAP THERAPEUTICS INC COM 52187K101 1,492 910,047 SH   SOLE   910,047 0 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 402 14,800 SH   SOLE   14,800 0 0
LIVANOVA PLC SHS G5509L101 2,334 27,745 SH   SOLE   27,745 0 0
LOUISIANA PAC CORP COM 546347105 202,300 3,355,446 SH   SOLE   2,881,286 0 474,160
LUMEN TECHNOLOGIES INC COM 550241103 828 60,907 SH   SOLE   60,907 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 56,790 552,052 SH   SOLE   433,228 0 118,824
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 95 1,941 SH   SOLE   1,941 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 3,136 320,698 SH   SOLE   320,698 0 0
MANULIFE FINL CORP COM 56501R106 101 5,111 SH   SOLE   5,111 0 0
MEDALLIA INC COM 584021109 30,577 905,984 SH   SOLE   784,575 0 121,409
MELCO RESORTS AND ENTMNT LTD ADR 585464100 42,819 2,584,151 SH   SOLE   2,584,151 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,506 110,906 SH   SOLE   110,906 0 0
MERUS N V COM N5749R100 4,530 214,974 SH   SOLE   214,974 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 279,516 1,866,676 SH   SOLE   1,666,879 0 199,797
MICRON TECHNOLOGY INC COM 595112103 296,818 3,492,802 SH   SOLE   3,120,939 0 371,863
MICROSOFT CORP COM 594918104 6,772 24,998 SH   SOLE   24,998 0 0
MOMO INC ADR 60879B107 104 6,773 SH   SOLE   6,773 0 0
MOSAIC CO NEW COM 61945C103 110,295 3,456,426 SH   SOLE   3,182,203 0 274,223
MOTOROLA SOLUTIONS INC COM NEW 620076307 611 2,818 SH   SOLE   2,818 0 0
MYOVANT SCIENCES LTD COM G637AM102 4,445 195,211 SH   SOLE   195,211 0 0
MYT NETHERLANDS PARENT B V ADS 55406W103 612 20,118 SH   SOLE   20,118 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 18,185 280,671 SH   SOLE   249,552 0 31,119
NIELSEN HLDGS PLC SHS EUR G6518L108 419 17,000 SH   SOLE   17,000 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102 64,748 1,371,789 SH   SOLE   1,371,789 0 0
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 19,907 1,656,143 SH   SOLE   1,656,143 0 0
ORACLE CORP COM 68389X105 2,007 25,784 SH   SOLE   25,784 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 3,302 752,108 SH   SOLE   752,108 0 0
ORGANON & CO COMMON STOCK 68622V106 4 125 SH   SOLE   125 0 0
OVID THERAPEUTICS INC COM 690469101 1,552 396,870 SH   SOLE   396,870 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 9,136 261,242 SH   SOLE   238,791 0 22,451
PAYPAL HLDGS INC COM 70450Y103 3,672 12,599 SH   SOLE   12,599 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 108 8,857 SH   SOLE   8,857 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 4,461 1,164,746 SH   SOLE   1,164,746 0 0
PLANET FITNESS INC CL A 72703H101 14,997 199,300 SH   SOLE   199,300 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 8,716 354,901 SH   SOLE   349,789 0 5,112
PROTHENA CORP PLC SHS G72800108 5,239 101,905 SH   SOLE   101,905 0 0
QUANTERIX CORP COM 74766Q101 30,180 514,488 SH   SOLE   468,515 0 45,973
RECURSION PHARMACEUTICALS IN CL A 75629V104 17,248 472,552 SH   SOLE   427,258 0 45,294
ROBLOX CORP CL A 771049103 2,925 32,504 SH   SOLE   32,504 0 0
ROKU INC COM CL A 77543R102 563 1,227 SH   SOLE   1,227 0 0
SANGAMO THERAPEUTICS INC COM 800677106 2,613 218,336 SH   SOLE   218,336 0 0
SIGNET JEWELERS LIMITED SHS G81276100 7,491 92,721 SH   SOLE   92,721 0 0
SILVERCREST METALS INC COM 828363101 26,900 3,081,352 SH   SOLE   2,366,555 0 714,797
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 27 1,000 SH   SOLE   1,000 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 80,676 420,735 SH   SOLE   335,559 0 85,176
SPROUTS FMRS MKT INC COM 85208M102 46 1,846 SH   SOLE   1,846 0 0
STATE STR CORP COM 857477103 48 583 SH   SOLE   583 0 0
SUNCOR ENERGY INC NEW COM 867224107 2,887 120,525 SH   SOLE   120,525 0 0
SUZANO S A SPON ADS 86959K105 14,945 1,241,314 SH   SOLE   1,241,314 0 0
SYNEOS HEALTH INC CL A 87166B102 9,643 107,754 SH   SOLE   107,754 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 32,731 1,297,317 SH   SOLE   1,297,317 0 0
TRIP COM GROUP LTD ADS 89677Q107 272,112 7,673,777 SH   SOLE   6,927,616 0 746,161
TWILIO INC CL A 90138F102 586 1,486 SH   SOLE   1,486 0 0
ULTA BEAUTY INC COM 90384S303 58,452 169,050 SH   SOLE   144,036 0 25,014
UNITED STATES STL CORP NEW COM 912909108 1,726 71,936 SH   SOLE   71,936 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 98 669 SH   SOLE   669 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 110 548 SH   SOLE   548 0 0
WABTEC COM 929740108 105,711 1,284,459 SH   SOLE   1,092,099 0 192,360
WARRIOR MET COAL INC COM 93627C101 13,934 810,120 SH   SOLE   676,820 0 133,300
WAVE LIFE SCIENCES LTD SHS Y95308105 1,375 206,384 SH   SOLE   206,384 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 3,609 206,915 SH   SOLE   206,915 0 0
XILINX INC COM 983919101 1,332 9,209 SH   SOLE   9,209 0 0
YUM CHINA HLDGS INC COM 98850P109 63,238 954,542 SH   SOLE   954,542 0 0
ZAI LAB LTD ADR 98887Q104 7,904 44,660 SH   SOLE   44,660 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 512,651 16,891,306 SH   SOLE   15,137,437 0 1,753,869
ZYMEWORKS INC COM 98985W102 3,571 102,944 SH   SOLE   102,944 0 0