The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
908 DEVICES INC COM 65443P102 1,629 33,580 SH   SOLE   33,580 0 0
ACCELERON PHARMA INC COM 00434H108 1,881 13,872 SH   SOLE   13,872 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 1,845 45,832 SH   SOLE   45,832 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 2,922 56,593 SH   SOLE   56,593 0 0
ALBIREO PHARMA INC COM 01345P106 2,225 63,121 SH   SOLE   63,121 0 0
ALECTOR INC COM 014442107 1,133 56,240 SH   SOLE   56,240 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 108,017 476,412 SH   SOLE   476,412 0 0
ALKERMES PLC SHS G01767105 3,040 162,716 SH   SOLE   162,716 0 0
ALLY FINL INC COM 02005N100 258,416 5,715,908 SH   SOLE   5,178,216 0 537,692
ALPHABET INC CAP STK CL A 02079K305 54,562 26,454 SH   SOLE   20,368 0 6,086
ALPHABET INC CAP STK CL C 02079K107 78,953 38,167 SH   SOLE   38,167 0 0
AMBARELLA INC SHS G037AX101 339 3,374 SH   SOLE   3,374 0 0
AMERICAN EAGLE OUTFITTERS IN COM 02553E106 89,651 3,066,056 SH   SOLE   2,569,882 0 496,174
AMERISOURCEBERGEN CORP COM 03073E105 100 845 SH   SOLE   845 0 0
AMGEN INC COM 031162100 103 414 SH   SOLE   414 0 0
ANALOG DEVICES INC COM 032654105 2,814 18,145 SH   SOLE   18,145 0 0
APPLE INC COM 037833100 1,562 12,788 SH   SOLE   12,788 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 2,331 56,445 SH   SOLE   56,445 0 0
ARCUS BIOSCIENCES INC COM 03969F109 2,114 75,290 SH   SOLE   75,290 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 1,725 514,984 SH   SOLE   514,984 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 6,583 1,431,120 SH   SOLE   1,431,120 0 0
AT&T INC COM 00206R102 146 4,823 SH   SOLE   4,823 0 0
ATRECA INC CL A COM 04965G109 2,196 143,274 SH   SOLE   143,274 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 327 15,000 SH   SOLE   15,000 0 0
AZIYO BIOLOGICS INC COM CL A 05479K106 1,954 141,395 SH   SOLE   141,395 0 0
BARRICK GOLD CORP COM 067901108 151,933 7,673,387 SH   SOLE   6,661,822 0 1,011,565
BIO RAD LABS INC CL A 090572207 4,330 7,581 SH   SOLE   7,581 0 0
BIOATLA INC COM 09077B104 1,714 33,705 SH   SOLE   33,705 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 1,716 168,715 SH   SOLE   168,715 0 0
BIONTECH SE SPONSORED ADS 09075V102 25,143 230,267 SH   SOLE   230,267 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,637 27,121 SH   SOLE   27,121 0 0
BOINGO WIRELESS INC COM 09739C102 1,663 118,198 SH   SOLE   118,198 0 0
BOOKING HOLDINGS INC COM 09857L108 104,260 44,750 SH   SOLE   37,477 0 7,273
CARDINAL HEALTH INC COM 14149Y108 4,528 74,529 SH   SOLE   74,529 0 0
CARVANA CO CL A 146869102 7,848 29,907 SH   SOLE   29,907 0 0
CEDAR FAIR L P DEPOSITRY UNIT 150185106 3,065 61,693 SH   SOLE   61,693 0 0
CENTOGENE N V COM N1976T109 5,393 444,595 SH   SOLE   444,595 0 0
CIENA CORP COM NEW 171779309 39,740 726,248 SH   SOLE   649,450 0 76,798
CISCO SYS INC COM 17275R102 1,846 35,700 SH   SOLE   35,700 0 0
COHERUS BIOSCIENCES INC COM 19249H103 6,885 471,285 SH   SOLE   471,285 0 0
CREDIT ACCEP CORP MICH COM 225310101 44 123 SH   SOLE   123 0 0
CUREVAC N V COM N2451R105 4,097 44,800 SH   SOLE   44,800 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 6,075 785,899 SH   SOLE   785,899 0 0
DENALI THERAPEUTICS INC COM 24823R105 1,758 30,791 SH   SOLE   30,791 0 0
DISH NETWORK CORPORATION CL A 25470M109 241 6,644 SH   SOLE   6,644 0 0
EBAY INC. COM 278642103 1,389 22,679 SH   SOLE   22,679 0 0
EQUIFAX INC COM 294429105 32,188 177,708 SH   SOLE   177,708 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 44,897 1,600,613 SH   SOLE   1,421,497 0 179,116
EXAGEN INC COM 30068X103 7,000 400,000 SH   SOLE   344,533 0 55,467
FACEBOOK INC CL A 30303M102 67,992 230,850 SH   SOLE   230,850 0 0
FEDEX CORP COM 31428X106 111,087 391,098 SH   SOLE   330,164 0 60,934
FIVE PRIME THERAPEUTICS INC COM 33830X104 6,893 182,993 SH   SOLE   182,993 0 0
FOX CORP CL A COM 35137L105 40 1,114 SH   SOLE   1,114 0 0
FREEPORT-MCMORAN INC CL B 35671D857 130,298 3,956,829 SH   SOLE   3,193,130 0 763,699
FULCRUM THERAPEUTICS INC COM 359616109 984 83,550 SH   SOLE   83,550 0 0
GENERAL ELECTRIC CO COM 369604103 322,193 24,538,685 SH   SOLE   21,111,984 0 3,426,701
GENETRON HLDGS LTD ADS 37186H100 14,958 697,015 SH   SOLE   697,015 0 0
GILEAD SCIENCES INC COM 375558103 107,890 1,669,344 SH   SOLE   1,412,605 0 256,739
GOLDMAN SACHS GROUP INC COM 38141G104 45 139 SH   SOLE   139 0 0
HANESBRANDS INC COM 410345102 92 4,670 SH   SOLE   4,670 0 0
HCA HEALTHCARE INC COM 40412C101 92 490 SH   SOLE   490 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 129,833 2,364,894 SH   SOLE   2,364,894 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 4,003 141,689 SH   SOLE   141,689 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 4,538 193,123 SH   SOLE   193,123 0 0
IHS MARKIT LTD SHS G47567105 2,387 24,660 SH   SOLE   24,660 0 0
IMMATICS N.V SHS N44445109 2,567 228,960 SH   SOLE   228,960 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,703 527,101 SH   SOLE   527,101 0 0
INHIBRX INC COM 45720L107 3,119 155,401 SH   SOLE   155,401 0 0
INOVALON HLDGS INC COM CL A 45781D101 253 8,800 SH   SOLE   8,800 0 0
INTEL CORP COM 458140100 2,146 33,533 SH   SOLE   33,533 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 2,987 37,225 SH   SOLE   37,225 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 20,078 179,781 SH   SOLE   144,501 0 35,280
INTERNATIONAL BUSINESS MACHS COM 459200101 199 1,494 SH   SOLE   1,494 0 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 49 9,805 SH   SOLE   9,805 0 0
JD.COM INC SPON ADR CL A 47215P106 51,558 611,379 SH   SOLE   611,379 0 0
KOHLS CORP COM 500255104 4,398 73,786 SH   SOLE   73,786 0 0
LAM RESEARCH CORP COM 512807108 79,390 133,375 SH   SOLE   118,979 0 14,396
LEAP THERAPEUTICS INC COM 52187K101 1,729 910,047 SH   SOLE   910,047 0 0
LIBERTY GLOBAL PLC SHS CL A G5480U104 380 14,800 SH   SOLE   14,800 0 0
LIVANOVA PLC SHS G5509L101 2,046 27,745 SH   SOLE   27,745 0 0
LOUISIANA PAC CORP COM 546347105 237,886 4,289,323 SH   SOLE   3,721,262 0 568,061
LUMEN TECHNOLOGIES INC COM 550241103 813 60,907 SH   SOLE   60,907 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 72,665 698,370 SH   SOLE   561,775 0 136,595
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 84 1,941 SH   SOLE   1,941 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 3,797 320,698 SH   SOLE   320,698 0 0
MANULIFE FINL CORP COM 56501R106 94 4,367 SH   SOLE   4,367 0 0
MEDALLIA INC COM 584021109 43,846 1,572,115 SH   SOLE   1,291,242 0 280,873
MELCO RESORTS AND ENTMNT LTD ADR 585464100 51,248 2,574,003 SH   SOLE   2,574,003 0 0
MERCK & CO. INC COM 58933Y105 96 1,250 SH   SOLE   1,250 0 0
MERSANA THERAPEUTICS INC COM 59045L106 1,794 110,906 SH   SOLE   110,906 0 0
MERUS N V COM N5749R100 4,491 214,974 SH   SOLE   214,974 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 299,845 1,931,739 SH   SOLE   1,731,942 0 199,797
MICRON TECHNOLOGY INC COM 595112103 317,621 3,600,735 SH   SOLE   3,228,872 0 371,863
MICROSOFT CORP COM 594918104 5,894 24,998 SH   SOLE   24,998 0 0
MOMO INC ADR 60879B107 84 5,714 SH   SOLE   5,714 0 0
MOSAIC CO NEW COM 61945C103 92,597 2,929,354 SH   SOLE   2,655,131 0 274,223
MOTOROLA SOLUTIONS INC COM NEW 620076307 530 2,818 SH   SOLE   2,818 0 0
MYOVANT SCIENCES LTD COM G637AM102 4,612 224,083 SH   SOLE   224,083 0 0
MYT NETHERLANDS PARENT B V ADS 55406W103 569 20,118 SH   SOLE   20,118 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 18,443 280,671 SH   SOLE   249,552 0 31,119
NIELSEN HLDGS PLC SHS EUR G6518L108 428 17,000 SH   SOLE   17,000 0 0
NOAH HLDGS LTD SPON ADS CL A 65487X102 64,677 1,456,691 SH   SOLE   1,456,691 0 0
OMNICOM GROUP INC COM 681919106 91 1,225 SH   SOLE   1,225 0 0
ONECONNECT FINL TECHNOLOGY C SPONSORED ADS 68248T105 27,639 1,870,058 SH   SOLE   1,870,058 0 0
ORACLE CORP COM 68389X105 2,261 32,220 SH   SOLE   32,220 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 4,545 625,969 SH   SOLE   625,969 0 0
OVID THERAPEUTICS INC COM 690469101 1,595 396,870 SH   SOLE   396,870 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 8,702 261,242 SH   SOLE   238,791 0 22,451
PAYPAL HLDGS INC COM 70450Y103 3,060 12,599 SH   SOLE   12,599 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 100 11,737 SH   SOLE   11,737 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,308 508,768 SH   SOLE   508,768 0 0
PLANET FITNESS INC CL A 72703H101 13,892 179,714 SH   SOLE   179,714 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 2,577 141,148 SH   SOLE   136,036 0 5,112
PROTHENA CORP PLC SHS G72800108 3,221 128,223 SH   SOLE   128,223 0 0
PRUDENTIAL FINL INC COM 744320102 92 1,015 SH   SOLE   1,015 0 0
QUANTERIX CORP COM 74766Q101 26,863 459,434 SH   SOLE   413,461 0 45,973
ROBLOX CORP CL A 771049103 387 5,962 SH   SOLE   5,962 0 0
ROKU INC COM CL A 77543R102 1,126 3,455 SH   SOLE   3,455 0 0
SANGAMO THERAPEUTICS INC COM 800677106 2,736 218,336 SH   SOLE   218,336 0 0
SCHLUMBERGER LTD COM 806857108 87 3,190 SH   SOLE   3,190 0 0
SIGNET JEWELERS LIMITED SHS G81276100 5,376 92,721 SH   SOLE   92,721 0 0
SILVERCREST METALS INC COM 828363101 18,584 2,300,000 SH   SOLE   1,844,304 0 455,696
SIX FLAGS ENTMT CORP NEW COM 83001A102 3,393 73,011 SH   SOLE   73,011 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 83,324 454,132 SH   SOLE   368,956 0 85,176
STATE STR CORP COM 857477103 49 583 SH   SOLE   583 0 0
STORE CAP CORP COM 862121100 95 2,821 SH   SOLE   2,821 0 0
SUZANO S A SPON ADS 86959K105 15,169 1,241,314 SH   SOLE   1,241,314 0 0
SYNEOS HEALTH INC CL A 87166B102 4,643 61,213 SH   SOLE   61,213 0 0
TRIP COM GROUP LTD ADS 89677Q107 301,569 7,609,603 SH   SOLE   6,930,945 0 678,658
TWILIO INC CL A 90138F102 506 1,486 SH   SOLE   1,486 0 0
ULTA BEAUTY INC COM 90384S303 50,957 164,818 SH   SOLE   137,173 0 27,645
UNIVERSAL HLTH SVCS INC CL B 913903100 89 669 SH   SOLE   669 0 0
UNUM THERAPEUTICS INC COM 19240Q201 6,426 731,903 SH   SOLE   707,070 0 24,833
VERTEX PHARMACEUTICALS INC COM 92532F100 96 448 SH   SOLE   448 0 0
WABTEC COM 929740108 71,801 907,035 SH   SOLE   803,648 0 103,387
WARRIOR MET COAL INC COM 93627C101 13,877 810,120 SH   SOLE   676,820 0 133,300
WAVE LIFE SCIENCES LTD SHS Y95308105 1,158 206,384 SH   SOLE   206,384 0 0
XILINX INC COM 983919101 1,141 9,209 SH   SOLE   9,209 0 0
YUM CHINA HLDGS INC COM 98850P109 60,787 1,026,627 SH   SOLE   1,026,627 0 0
ZAI LAB LTD ADR 98887Q104 5,959 44,660 SH   SOLE   44,660 0 0
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 348,596 11,958,705 SH   SOLE   10,757,642 0 1,201,063
ZYMEWORKS INC COM 98985W102 3,251 102,944 SH   SOLE   102,944 0 0