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  <xs:element id="cbio_ParagonOptionAgreementsMember" abstract="true" name="ParagonOptionAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_ParascentWarrantMember" abstract="true" name="ParascentWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_ClassOfWarrantsOrRightsPercentOfOutstandingSharesFullyDilutedBasis" abstract="false" name="ClassOfWarrantsOrRightsPercentOfOutstandingSharesFullyDilutedBasis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cbio_ParagonTherapeuticsMember" abstract="true" name="ParagonTherapeuticsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_KelunBiotechMember" abstract="true" name="KelunBiotechMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_CR001Member" abstract="true" name="CR001Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_CR002Member" abstract="true" name="CR002Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_SKB105Member" abstract="true" name="SKB105Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_AssetAcquisitionMaximumAggregateMilestonePayments" abstract="false" name="AssetAcquisitionMaximumAggregateMilestonePayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cbio_AssetAcquisitionNumberOfEmployeesOverseeingAndCoordinatingResearchProject" abstract="false" name="AssetAcquisitionNumberOfEmployeesOverseeingAndCoordinatingResearchProject" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cbio_AssetAcquisitionNumberOfVotesOptionAgreement" abstract="false" name="AssetAcquisitionNumberOfVotesOptionAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cbio_AssetAcquisitionOptionAgreementTerminationPeriodMaximumContractualPeriod" abstract="false" name="AssetAcquisitionOptionAgreementTerminationPeriodMaximumContractualPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cbio_ClassOfWarrantsOrRightsPercentOfOutstandingShares" abstract="false" name="ClassOfWarrantsOrRightsPercentOfOutstandingShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cbio_AssetAcquisitionMaximumAggregateMilestonePayments1" abstract="false" name="AssetAcquisitionMaximumAggregateMilestonePayments1" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cbio_AssetAcquisitionLicenseAgreementRestrictionPeriod" abstract="false" name="AssetAcquisitionLicenseAgreementRestrictionPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cbio_AssetAcquisitionRoyaltyPercentPaidReductionDueToInvalidPatent" abstract="false" name="AssetAcquisitionRoyaltyPercentPaidReductionDueToInvalidPatent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cbio_AssetAcquisitionOptionAgreementTerminationPeriodBreachOfContract" abstract="false" name="AssetAcquisitionOptionAgreementTerminationPeriodBreachOfContract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cbio_AssetAcquisitionOptionAgreementSublicenseAgreementPeriod" abstract="false" name="AssetAcquisitionOptionAgreementSublicenseAgreementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cbio_ContractWithCustomerCollaborativeArrangementConsiderationTransferredPeriod" abstract="false" name="ContractWithCustomerCollaborativeArrangementConsiderationTransferredPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cbio_ContractWithCustomerCollaborativeArrangementDevelopmentMilestonePaymentsMaximum" abstract="false" name="ContractWithCustomerCollaborativeArrangementDevelopmentMilestonePaymentsMaximum" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cbio_ContractWithCustomerCollaborativeArrangementCombinationStudyApprovalPayment" abstract="false" name="ContractWithCustomerCollaborativeArrangementCombinationStudyApprovalPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cbio_AssetAcquisitionDevelopmentMilestonePaymentsMaximum" abstract="false" name="AssetAcquisitionDevelopmentMilestonePaymentsMaximum" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cbio_AssetAcquisitionSalesBasedMilestonePaymentsMaximum" abstract="false" name="AssetAcquisitionSalesBasedMilestonePaymentsMaximum" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cbio_AssetAcquisitionSaleBasedMilestonePaymentMidSingleDigitsToLowDoubleDigitsRoyaltyPaymentPeriod" abstract="false" name="AssetAcquisitionSaleBasedMilestonePaymentMidSingleDigitsToLowDoubleDigitsRoyaltyPaymentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cbio_AssetAcquisitionSaleBasedMilestonePaymentLowSingleDigitsToLowDoubleDigitsRoyaltyPaymentPeriod" abstract="false" name="AssetAcquisitionSaleBasedMilestonePaymentLowSingleDigitsToLowDoubleDigitsRoyaltyPaymentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cbio_WalthamMassachusettsMember" abstract="true" name="WalthamMassachusettsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_CellLineLicenseAgreementMember" abstract="true" name="CellLineLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_WuXiBiologicsIrelandLimitedMember" abstract="true" name="WuXiBiologicsIrelandLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_LossContingencyLossesIncurredToDate" abstract="false" name="LossContingencyLossesIncurredToDate" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cbio_OptionAgreementRoyaltyPaymentPercentOfNetSales" abstract="false" name="OptionAgreementRoyaltyPaymentPercentOfNetSales" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cbio_OptionAgreementTerminationPeriod" abstract="false" name="OptionAgreementTerminationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cbio_OptionAgreementTerminationPeriodBreachOfContract" abstract="false" name="OptionAgreementTerminationPeriodBreachOfContract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cbio_OptionAgreementTerminationPeriodFailureToPay" abstract="false" name="OptionAgreementTerminationPeriodFailureToPay" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cbio_CrescentBiopharmaMember" abstract="true" name="CrescentBiopharmaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_ParascentHoldingLLCMember" abstract="true" name="ParascentHoldingLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_AccruedResearchAndDevelopmentMember" abstract="true" name="AccruedResearchAndDevelopmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_AccruedGeneralAndAdministrativeMember" abstract="true" name="AccruedGeneralAndAdministrativeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_DiscoveryExternalResearchAndDevelopmentCostsMember" abstract="true" name="DiscoveryExternalResearchAndDevelopmentCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cbio_PersonnelCosts" abstract="false" name="PersonnelCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cbio_MilestoneAndLicenseFees" abstract="false" name="MilestoneAndLicenseFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
