X0306 4 2022-07-27 0 0001253176 VAPOTHERM INC VAPO 0001333002 Spence Donald J 100 DOMAIN DRIVE EXETER NH 03833 1 0 0 0 Common Stock 20579 D Stock Option (right to buy) 2.31 2022-07-27 4 A 0 8717 0 A 2032-07-27 Common Stock 8717 8717 D Includes 5,527 shares that will be issued over time upon vesting and settlement of restricted stock units granted under the Vapotherm, Inc. 2018 Equity Incentive Plan (as amended from time to time, the "2018 Equity Plan"). This option was granted under the 2018 Equity Plan and will vest in full on the earlier of the first anniversary of the date of grant or the Issuer's 2023 annual meeting of stockholders, subject to the Reporting Person's continued service as a director of the Issuer through the vesting date. /s/ Adrain Bryant, as Attorney In Fact 2022-08-04