X0306 4 2016-02-28 0001532063 Express Scripts Holding Co. ESRX 0001252016 WENTWORTH TIMOTHY C C/O EXPRESS SCRIPTS HOLDING COMPANY ONE EXPRESS WAY ST. LOUIS MO 63121 1 1 0 0 President Common Stock 2016-02-28 4 F 0 6636 71.33 D 94190.667 D Phantom Stock Unit 0 2016-02-29 4 A 0 357.4026 70.38 A Express Scripts Holding Company Common Stock 357.4026 1058.0404 D Represents shares tendered to Company to cover Reporting Person's tax liability due upon vesting of restricted stock units previously awarded under long-term incentive plans. Phantom Stock Unit credited under the Company's Executive Deferred Compensation Plan. Upon distribution each Phantom Stock Unit converts to one share of the Company's Common Stock. Basic Company Credit by Express Scripts Holding Company to Participant's Account in the Executive Deferred Compensation Plan; shares vest 3 (three) years after the plan year to which such credit relates. /s/ Martin P. Akins, as Attorney-in-Fact for Timothy C. Wentworth 2016-03-01