<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001250333</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001327567</issuerCik>
      <issuerName>Palo Alto Networks, Inc.</issuerName>
      <secFileNumber>001-35594</secFileNumber>
      <issuerAddress>
        <com:street1>3000 Tannery Way</com:street1>
        <com:city>Santa Clara</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>95054</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>408-753-4000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Nir Zuk</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Affiliate</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>J.P. Morgan Securities LLC</name>
        <address>
          <com:street1>390 Madison Avenue</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>300000</noOfUnitsSold>
      <aggregateMarketValue>61086000</aggregateMarketValue>
      <noOfUnitsOutstanding>668900000</noOfUnitsOutstanding>
      <approxSaleDate>10/01/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/07/2005</acquiredDate>
      <natureOfAcquisitionTransaction>Shares acquired as founder shares by Nir Zuk from the issuer</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>300000</amountOfSecuritiesAcquired>
      <paymentDate>03/07/2005</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Hawk Family Trust</name>
        <address>
          <com:street1>Care of Palo Alto Networks Inc</com:street1>
          <com:street2>3000 Tannery Way</com:street2>
          <com:city>Santa Clara</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>95054</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>08/01/2025</saleDate>
      <amountOfSecuritiesSold>100000</amountOfSecuritiesSold>
      <grossProceeds>17280459</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Hawk Family Trust</name>
        <address>
          <com:street1>Care of Palo Alto Networks Inc</com:street1>
          <com:street2>3000 Tannery Way</com:street2>
          <com:city>Santa Clara</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>95054</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>09/02/2025</saleDate>
      <amountOfSecuritiesSold>100000</amountOfSecuritiesSold>
      <grossProceeds>17280459</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The shares covered by this filing are shares expected to be sold within 3 months of this filing by Hawk Family Trust Dtd 10/29/12 (Nir Zuk as Trustee).</remarks>
    <noticeSignature>
      <noticeDate>10/01/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>01/09/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Nir Zuk</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
