X0306 4 2018-06-13 0 0001581720 Loxo Oncology, Inc. LOXO 0001250195 ELMS STEVE 888 SEVENTH AVENUE 12TH FLOOR NEW YORK NY 10106 1 0 1 0 Director Stock Option (right to buy) 180.98 2018-06-13 4 A 0 8750 0 A 2028-06-12 Common Stock 8750 8750 D The stock option vests and becomes exercisable in 12 equal monthly installments beginning one month after the grant date, until such time as the option is 100% vested, subject to the continuing service of the Reporting Person on each vesting date. These stock options are held by Mr. Elms for the benefit of Aisling Capital LLC. Mr. Elms disclaims beneficial ownership of these securities and this report is not an admission that he is the beneficial owner of such securities for purposes of Section 16 or any other purposes, except to the extent of his pecuniary interest therein. /s/ Steve Elms 2018-06-14