X0303 4 2010-11-08 0000858803 AVANIR PHARMACEUTICALS, INC. AVNR 0001431445 Clarus Lifesciences I, L.P. C/O CLARUS VENTURES, LLC 101 MAIN STREET, SUITE 1210 CAMBRIDGE MA 02142 0 0 1 0 0001431442 Clarus Ventures I GP, L.P. C/O CLARUS VENTURES, LLC 101 MAIN STREET, SUITE 1210 CAMBRIDGE MA 02142 0 0 1 0 0001431441 Clarus Ventures I, LLC C/O CLARUS VENTURES, LLC 101 MAIN STREET, SUITE 1210 CAMBRIDGE MA 02142 0 0 1 0 0001252523 LIPTAK ROBERT C/O CLARUS VENTURES, LLC 101 MAIN STREET, SUITE 1210 CAMBRIDGE MA 02142 0 0 1 0 0001431403 Simon Nicholas C/O CLARUS VENTURES, LLC 101 MAIN STREET, SUITE 1210 CAMBRIDGE MA 02142 0 0 1 0 0001249153 HENNER DENNIS C/O CLARUS VENTURES, LLC 101 MAIN STREET, SUITE 1210 CAMBRIDGE MA 02142 0 0 1 0 0001252522 GALAKATOS NICHOLAS C/O CLARUS VENTURES, LLC 101 MAIN STREET, SUITE 1210 CAMBRIDGE MA 02142 0 0 1 0 0001252525 WHEELER KURT C/O CLARUS VENTURES, LLC 101 MAIN STREET, SUITE 1210 CAMBRIDGE MA 02142 0 0 1 0 0001166285 STEINMETZ MICHAEL C/O CLARUS VENTURES, LLC 101 MAIN STREET, SUITE 1210 CAMBRIDGE MA 02142 0 0 1 0 Common Stock 2010-11-08 4 S 0 44626 5.10 D 7869216 I By Fund Common Stock 2010-11-09 4 S 0 1200000 4.8116 D 6669216 I By Fund Securities held of record by Clarus Lifesciences I, L.P. (the "Fund"). Clarus Ventures I GP, L.P. (the "GPLP"), controls the general partner of the Fund and may be deemed to beneficially own certain of the shares held of record by the Fund. The GPLP disclaims beneficial ownership of all shares held of record by the Fund in which the GPLP does not have an actual pecuniary interest. Clarus Ventures I, LLC (the "GPLLC"), as the sole general partner of the GPLP, may be deemed to beneficially own certain of the shares held of record by the Fund. Each of Messrs. Galakatos, Henner, Liptak, Simon, Steinmetz and Wheeler, as individual Managing Directors of the GPLLC, may be deemed to beneficially own certain of the shares held of record by the Fund. Each of the GPLLC and Messrs. Galakatos, Henner, Liptak, Simon, Steinmetz and Wheeler disclaims beneficial ownership of all shares held of record by the Fund in which he does not have an actual pecuniary interest. /s/ Robert Liptak, Manager of Clarus Ventures I, LLC, general partner of Clarus Ventures I GP, L.P., general partner of Clarus Lifesciences I, L.P. 2010-11-10 /s/ Robert Liptak, Manager of Clarus Ventures I, LLC, general partner of Clarus Ventures I GP, L.P. 2010-11-10 /s/ Robert Liptak, Manager of Clarus Ventures I, LLC 2010-11-10 /s/ Robert Liptak, as attorney-in-fact for Nicholas Simon 2010-11-10 /s/ Robert Liptak 2010-11-10 /s/ Robert Liptak, as attorney-in-fact for Dennis Henner 2010-11-10 /s/ Robert Liptak, as attorney-in-fact for Nicholas Galakatos 2010-11-10 /s/ Robert Liptak, as attorney-in-fact for Kurt Wheeler 2010-11-10 /s/ Robert Liptak, as attorney-in-fact for Michael Steinmetz 2010-11-10