X0306 4 2016-01-04 0 0001124140 EXACT SCIENCES CORP EXAS 0001247296 COWARD D SCOTT 441 CHARMANY DRIVE MADISON WI 53719 0 1 0 0 SVP and General Counsel Common Stock 2016-01-04 4 M 0 18750 0.00 A 19550 D Common Stock 2016-01-05 4 S 0 7074 9.05 D 12476 D Restricted Stock Units 2016-01-04 4 M 0 18750 0.00 D Common Stock 18750 56250 D Represents shares of common stock received upon vesting of a restricted stock unit award that vested on January 1, 2016 and settled on January 4, 2016. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain shares of restricted stock that vested on January 1, 2016 and settled on January 4, 2016. Each restricted stock unit represents a contingent right to receive one share of common stock. Represents a restricted stock unit award granted on January 1, 2015 that partially vested on January 1, 2016. The restricted stock units vest as follows: one-quarter on the first anniversary of the grant date and the balance in equal quarterly installments over the three year period beginning on the one-year anniversary of the grant date. /s/ D. Scott Coward by Mark R. Busch, attorney-in-fact 2016-01-06