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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001209191-08-038723.txt : 20080624
<SEC-HEADER>0001209191-08-038723.hdr.sgml : 20080624
<ACCEPTANCE-DATETIME>20080624202245
ACCESSION NUMBER:		0001209191-08-038723
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080618
FILED AS OF DATE:		20080624
DATE AS OF CHANGE:		20080624

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CELGENE CORP /DE/
		CENTRAL INDEX KEY:			0000816284
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				222711928
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0501

	BUSINESS ADDRESS:	
		STREET 1:		86 MORRIS AVENUE
		CITY:			SUMMIT
		STATE:			NJ
		ZIP:			07901
		BUSINESS PHONE:		(908)673-9000

	MAIL ADDRESS:	
		STREET 1:		86 MORRIS AVENUE
		CITY:			SUMMIT
		STATE:			NJ
		ZIP:			07901

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			KAPLAN GILLA
		CENTRAL INDEX KEY:			0001247024

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-16132
		FILM NUMBER:		08915407

	BUSINESS ADDRESS:	
		STREET 1:		C/O CELGENE CORP
		STREET 2:		7 POWDER HORN DR
		CITY:			WARREN
		STATE:			NJ
		ZIP:			07059
		BUSINESS PHONE:		732271100

	MAIL ADDRESS:	
		STREET 1:		C/O CELGENE CORPORATION
		STREET 2:		86 MORRIS AVENUE
		CITY:			SUMMIT
		STATE:			NJ
		ZIP:			07901

	FORMER NAME:	
		FORMER CONFORMED NAME:	KAPLAN GILLA  PHD
		DATE OF NAME CHANGE:	20030625
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>y61681_gk.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-06-18</periodOfReport>

    <issuer>
        <issuerCik>0000816284</issuerCik>
        <issuerName>CELGENE CORP /DE/</issuerName>
        <issuerTradingSymbol>CELG</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001247024</rptOwnerCik>
            <rptOwnerName>KAPLAN GILLA</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CELGENE CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>86 MORRIS AVENUE</rptOwnerStreet2>
            <rptOwnerCity>SUMMIT</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>07901</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>60.02</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2008-06-18</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>13875</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2018-06-18</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>13875</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>13875</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Option will vest and become exercisable on the earlier of June 18, 2009 and the date of the next annual stockholders' meeting.</footnote>
        <footnote id="F2">Option granted pursuant to the Company's 1995 Non-Employee Directors' Incentive Plan.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Robert J. Hugin, attorney-in-fact</signatureName>
        <signatureDate>2008-06-24</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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