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    <periodOfReport>2016-11-29</periodOfReport>

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    <issuer>
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        <issuerName>Aegerion Pharmaceuticals, Inc.</issuerName>
        <issuerTradingSymbol>AEGR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
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            <rptOwnerCik>0001247015</rptOwnerCik>
            <rptOwnerName>BARER SOL J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O AEGERION PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>ONE MAIN STREET, SUITE 800</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02142</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
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            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
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    <footnotes>
        <footnote id="F1">Disposed of in exchange for 30,665 common shares of Novelion Therapeutics Inc. pursuant to the Agreement and Plan of Merger (the &quot;Merger Agreement&quot;), dated as of June 14, 2016, by and among the Issuer, QLT Inc. (&quot;QLT&quot;) and Isotope Acquisition Corp. (&quot;Isotope&quot;), pursuant to which Isotope was merged with and into the Issuer, effective November 29, 2016. Following completion of the merger, QLT was renamed &quot;Novelion Therapeutics Inc.&quot;</footnote>
        <footnote id="F2">Pursuant to the Merger Agreement, at the effective time of the merger, each option to acquire common stock of the Issuer that was outstanding and unexercised immediately prior to the effective time of the merger that had an exercise price per share equal to or greater than $1.88 (the product obtained by multiplying (i) the exchange ratio of 1.0256 by (ii) $1.83, the closing price of a QLT common share on November 28, 2016) was cancelled without any payment or other consideration therefor.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Jennifer Fitzpatrick, Attorney-in-fact</signatureName>
        <signatureDate>2016-11-30</signatureDate>
    </ownerSignature>
</ownershipDocument>
