X0508 4 2025-10-16 0001628171 Revolution Medicines, Inc. RVMD 0001246842 GOLDSMITH MARK A C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 true true See Remarks true Common Stock 2025-10-16 4 M 0 10000 1.12 A 462309 D Common Stock 2025-10-16 4 S 0 10000 50.4701 D 452309 D Common Stock 2025-10-17 4 M 0 10000 1.12 A 462309 D Common Stock 2025-10-17 4 S 0 10000 55 D 452309 D Common Stock 20424 I Trust Common Stock 20424 I Trust Common Stock 465604 I Trust Stock Option (Right to Buy) 1.12 2025-10-16 4 M 0 10000 0 D 2022-03-29 2028-04-19 Common Stock 10000 36479 D Stock Option (Right to Buy) 1.12 2025-10-17 4 M 0 10000 0 D 2022-03-29 2028-04-19 Common Stock 10000 26479 D Transaction made pursuant to a 10b5-1 trading plan adopted by Mark A. Goldsmith on December 19, 2024. Includes 193,475 restricted stock units. This transaction was executed in multiple trades at prices ranging from $50.00 to $50.93. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Held by Jonathan Goldsmith Revocable Trust. Held by Rebecca Eve Goldsmith Trust under the Goldsmith Children's 2011 Irrevocable Education Trust, dated December 15, 2011. Held by Mark A. Goldsmith and Anne E. Midler 2002 Revocable Living Trust. President and Chief Executive Officer /s/ Jack Anders, as attorney-in fact for Mark A. Goldsmith 2025-10-20