X0306 4 2021-04-12 0 0001770787 10x Genomics, Inc. TXG 0001246406 CRUTCHFIELD BRADFORD C/O 10X GENOMICS, INC. 6230 STONERIDGE MALL ROAD PLEASANTON CA 94588 0 1 0 0 Chief Commercial Officer Class A Common Stock 2021-04-12 4 M 0 17000 1.16 A 51608 D Class A Common Stock 2021-04-12 4 S 0 907 181.1029 D 50701 D Class A Common Stock 2021-04-12 4 S 0 2642 181.8419 D 48059 D Class A Common Stock 2021-04-12 4 S 0 1302 182.7479 D 46757 D Class A Common Stock 2021-04-12 4 S 0 600 184.3186 D 46157 D Class A Common Stock 2021-04-12 4 S 0 1500 185.1427 D 44657 D Class A Common Stock 2021-04-12 4 S 0 2855 186.3085 D 41802 D Class A Common Stock 2021-04-12 4 S 0 1996 187.0991 D 39806 D Class A Common Stock 2021-04-12 4 S 0 2398 188.3631 D 37408 D Class A Common Stock 2021-04-12 4 S 0 1400 189.3395 D 36008 D Class A Common Stock 2021-04-12 4 S 0 1100 190.3095 D 34908 D Class A Common Stock 2021-04-12 4 S 0 300 192.1733 D 34608 D Stock Option (right to buy) 1.16 2021-04-12 4 M 0 17000 0.00 D 2027-02-03 Class A Common Stock 17000 562000 D The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person. This transaction was executed in multiple trades at prices ranging from $180.39 to $181.28. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $181.39 to $182.29. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $182.54 to $183.29. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $183.67 to $184.61. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $184.67 to $185.62. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $185.755 to $186.75. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $186.76 to $187.59. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $187.98 to $188.94. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $188.98 to $189.90. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $190.01 to $191.68. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This transaction was executed in multiple trades at prices ranging from $192.00 to $192.52. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. This option, originally for 800,000 shares, of which 238,000 shares have been exercised, vested as to one-fourth of the shares on February 2, 2018 and one forty-eighth of the shares subject to the option vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date. /s/ Eric S. Whitaker, as Attorney-in-Fact 2021-04-13