<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-11-09</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000890801</issuerCik>
        <issuerName>McAfee, Inc.</issuerName>
        <issuerTradingSymbol>MFE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001246207</rptOwnerCik>
            <rptOwnerName>DE CESARE MICHAEL P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MCAFEE, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>5000 HEADQUARTERS DRIVE</rptOwnerStreet2>
            <rptOwnerCity>PLANO</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>75024</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>EVP Worldwide Sales Operations</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2010-11-09</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>32472</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>47.3352</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>65148</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes></footnotes>

    <remarks>As has been widely reported, the capital gains and personal income tax rates are expected to increase, effective January 1, 2011.  For this reason, the Reporting Person is selling the vested stock units specified herein prior to December 31, 2010.  The Reporting Person believes that this is the appropriate time for the sales reflected herein in light of the following: (i) the Issuer's disclosure on October 28, 2010 of its Q3 2010 earnings and that the acquisition of the Issuer by Intel is still expected to close by mid next year, (ii) the Issuer's disclosure on November 2, 2010 of the results of the November 2, 2010 stockholder vote approving the acquisition of the Issuer by Intel, and (iii) the opening of the Issuer's trading window for insiders pursuant to its insider trading policy.</remarks>

    <ownerSignature>
        <signatureName>Jared Ross, Attorney-in-Fact</signatureName>
        <signatureDate>2010-11-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
