<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2017-01-01</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001660484</issuerCik>
        <issuerName>Innocoll Holdings plc</issuerName>
        <issuerTradingSymbol>INNL</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001380393</rptOwnerCik>
            <rptOwnerName>Fortress Investment Group LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1345 AVENUE OF THE AMERICAS</rptOwnerStreet1>
            <rptOwnerStreet2>46TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001500292</rptOwnerCik>
            <rptOwnerName>Hybrid GP Holdings LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1345 AVENUE OF THE AMERICAS</rptOwnerStreet1>
            <rptOwnerStreet2>46TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001387344</rptOwnerCik>
            <rptOwnerName>Fortress Operating Entity I LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1345 AVENUE OF THE AMERICAS</rptOwnerStreet1>
            <rptOwnerStreet2>46TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001387345</rptOwnerCik>
            <rptOwnerName>FIG Corp.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1345 AVENUE OF THE AMERICAS</rptOwnerStreet1>
            <rptOwnerStreet2>46TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001245521</rptOwnerCik>
            <rptOwnerName>FIG LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1345 AVENUE OF THE AMERICAS</rptOwnerStreet1>
            <rptOwnerStreet2>46TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Ordinary Shares</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4085469</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                    <footnoteId id="F6"/>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Warrants to purchase Ordinary Shares</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>7.39</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2016-03-16</value>
            </exerciseDate>
            <expirationDate>
                <value>2019-06-15</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Ordinary Shares</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>929156</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                    <footnoteId id="F6"/>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Cam Investment Cayman Holdings L.P. (&quot;Cam Investment&quot;), a Cayman Islands limited partnership, directly holds the securities of the Issuer.</footnote>
        <footnote id="F2">The general partner of Cam Investment is Cam Investment Cayman Holdings GP Inc. FCOF II Europe UB Securities DAC (&quot;FCOF II DAC&quot;), FTS SIP (Europe) DAC (&quot;FTS SIP DAC&quot;), FCO MA II Europe UB Securities DAC (&quot;MA II DAC&quot;), FCO Europe MA LSS Limited (&quot;LSS Limited&quot;), FGO (Yen) Investments DAC (&quot;FGO Yen DAC&quot;) and FCO Europe MA ML DAC (&quot;MA ML DAC&quot;) collectively hold a 100% interest in Cam Investment and its general partner Cam Investment Cayman Holdings GP Inc.</footnote>
        <footnote id="F3">FCOF II UB Securities LLC (&quot;FCOF II UB Securities&quot;) holds a 70% interest in FCOF II DAC. Fortress Credit Opportunities Fund II (A) LP (&quot;FCOF II A&quot;), FCOF II UB Holdings Ltd. (&quot;UB Holdings&quot;) and Fortress Credit Opportunities Fund II (E) LP (&quot;FCOF II E&quot;) collectively hold a 100% interest in FCOF II UB Securities. FCOF II BCD Holdings LLC (&quot;BCD Holdings&quot;) holds a 100% interest in UB Holdings. Fortress Credit Opportunities Fund II (B) LP (&quot;FCOF II B&quot;), Fortress Credit Opportunities Fund II (C) L.P. (&quot;FCOF II C&quot;) and Fortress Credit Opportunities Fund II (D) L.P. (&quot;FCOF II D&quot;) collectively hold a 100% interest in BCD Holdings. FCO Fund II GP LLC (&quot;FCO II GP&quot;) is the general partner of each of FCOF II A, FCOF II B, FCOF II C, FCOF II D and FCOF II E.</footnote>
        <footnote id="F4">Fortress Credit Opportunities Advisors LLC (&quot;FCO Advisors&quot;) is the investment advisor of each of FCOF II A, FCOF II B, FCOF II C, FCOF II D and FCOF II E. FTS SIP L.P. (&quot;FTS SIP&quot;) holds a 70% interest in FTS SIP DAC. FCO MA GP LLC (&quot;FCO MA GP&quot;) is the general partner of FTS SIP. Fortress Credit Opportunities MA Advisors LLC (&quot;FCO MA Advisors&quot;) is the investment advisor of FTS SIP. FCO MA II UB Securities LLC (&quot;FCO MA II UB Securities&quot;) holds a 70% interest in MA II DAC. FCO MA II LP (&quot;FCO MA II&quot;) holds a 100% interest in FCO MA II UB Securities. FCO MA II GP LLC (&quot;FCO MA II GP&quot;) is the general partner of FCO MA II. Fortress Credit Opportunities MA II Advisors LLC (&quot;FCO MA II Advisors&quot;) is the investment advisor of FCO MA II. FCO MA LSS LP (&quot;FCO MA LSS&quot;) holds a 70% interest in LSS Limited. FCO MA LSS GP LLC (&quot;FCO MA LSS GP&quot;) is the general partner of FCO MA LSS. FCO MA LSS Advisors LLC (&quot;FCO MA LSS Advisors&quot;) is the investment advisor of FCO MA LSS.</footnote>
        <footnote id="F5">Fortress Global Opportunities (Yen) Fund L.P. (&quot;FGO Yen&quot;) holds a 70% interest in FGO Yen DAC. FGO (Yen) GP LLC (&quot;FGO Yen GP&quot;) is the general partner of FGO Yen. Fortress Global Opportunities (Yen) Advisors LLC (&quot;FGO Yen Advisors&quot;) is the investment advisor of FGO Yen. FCO MA Maple Leaf LP (&quot;FCO MAPLE LEAF&quot;) and FCO MA MAPLE LEAF GP LLC (&quot;FCO MAPLE LEAF GP&quot;) hold a 70% interest in MA ML DAC. FCO MAPLE LEAF GP is the general partner of FCO MAPLE LEAF.</footnote>
        <footnote id="F6">Fortress Credit Opportunities MA MAPLE LEAF Advisors LLC (&quot;FCO MAPLE LEAF Advisors&quot;) is the investment advisor of FCO MAPLE LEAF. Hybrid GP Holdings LLC (&quot;Hybrid GP Holdings&quot;) holds a 100% interest in each of FCO II GP, FCO MA GP, FCO MA II GP, FCO MA LSS GP, FGO Yen GP and FCO MAPLE LEAF GP. Fortress Operating Entity I LP (&quot;FOE I&quot;) is the sole managing member of Hybrid GP Holdings. FIG LLC (&quot;FIG&quot;) holds a 100% interest in FCO Advisors, FCO MA Advisors, FCO MA II Advisors, FCO MA LSS Advisors, FGO Yen Advisors and FCO MAPLE LEAF Advisors. FOE I is the sole managing member of FIG. FIG Corp. is the general partner of FOE I. FIG Corp. is wholly-owned by Fortress Investment Group LLC.</footnote>
        <footnote id="F7">Each reporting person disclaims beneficial ownership of all reported shares except to the extent of its pecuniary interest therein and the inclusion of the shares in this report shall not be deemed to be an admission of beneficial ownership of the reported shares for the purposes of Section 16 or otherwise.</footnote>
    </footnotes>

    <remarks>The reporting persons are filing this form in connection with the Issuer's transition from reporting as a foreign private issuer to reporting as a domestic issuer, effective January 1, 2017.</remarks>

    <ownerSignature>
        <signatureName>/s/ FORTRESS INVESTMENT GROUP LLC, by David N. Brooks, its Secretary</signatureName>
        <signatureDate>2017-01-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ HYBRID GP HOLDINGS LLC, by Fortress Operating Entity I LP, its sole managing member, by FIG Corp., its general partner, by David N. Brooks, its Secretary</signatureName>
        <signatureDate>2017-01-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ FORTRESS OPERATING ENTITY I LP, by FIG Corp., its general partner, by David N. Brooks, its Secretary</signatureName>
        <signatureDate>2017-01-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ FIG Corp., by David N. Brooks, its Secretary</signatureName>
        <signatureDate>2017-01-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ FIG LLC, by David N. Brooks, its Secretary</signatureName>
        <signatureDate>2017-01-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
