X0306 4 2015-03-09 0 0001371217 EnteroMedics Inc ETRM 0001243513 KNUDSON MARK B 2800 PATTON ROAD ST. PAUL MN 55113 1 1 0 0 Chrmn, Pres & CEO Common Stock 1382 I Spouse Revocable Trust Common Stock 3215 I Family Limited Partnership Common Stock 57571 I Revocable Trust 2003 Stock Option (right to buy) 2.76 2015-04-27 Common Stock 7915 7915 D Stock Option (right to buy) 2.76 2016-04-20 Common Stock 6776 6776 D Stock Option (right to buy) 1.90 2010-10-29 2017-10-29 Common Stock 33432 33432 D Stock Option (right to buy) 1.90 2010-10-29 2017-10-29 Common Stock 25902 25902 D Stock Option (right to buy) 1.90 2010-10-29 2017-10-29 Common stock 44131 44131 D Stock Option (right to buy) 1.90 2010-10-29 2017-10-29 Common Stock 50472 50472 D Stock Option (right to buy) 3.78 2019-11-18 Common Stock 20833 20833 D Warrant (common stock right to buy) 2.19 Common Stock 25000 25000 D Stock Option (right to buy) 2.58 2011-03-16 2021-02-16 Common Stock 350000 350000 D Stock Option (right to buy) 2.67 2011-08-12 2021-07-12 Common Stock 350000 350000 D Stock Option (right to buy) 1.90 2012-01-14 2021-12-14 Common Stock 200000 200000 D Stock Option (right to buy) 3.35 2012-08-10 2022-07-10 Common Stock 1292225 1292225 D Stock Option (right to buy) 1.31 2013-06-30 2013-05-31 Common Stock 1278730 1278730 D Stock Option (right to buy) 1.11 2015-03-09 4 A 0 225000 0.00 A 2015-04-09 2025-03-09 Common Stock 225000 225000 D Options currently 100% vested. Options vest 33% on date noted and thereafter at 124th per month. Warrant becomes exercisable 181 days from the date of issuance at close of offering. Warrant expires five years from the date it becomes exercisable. Vests in increments of 1/48th per month, beginning the date shown. The exercise price is the closing price on July 10, 2012, the date the board authorized the grants subject to stockholder approval of the increase in the number of shares available for awards under the incentive plan, which was obtained on September 27, 2012. /s/ Greg S. Lea, Attorney in Fact for Mark B. Knudson 2015-03-11