X0306 4 2018-03-12 0 0001585608 Jaguar Health, Inc. JAGX 0001243187 MICEK JOHN C/O JAGUAR HEALTH, INC. 201 MISSION STREET, SUITE 2375 SAN FRANCISCO CA 94105 1 0 0 0 Stock Option (right to buy) 8.40 2018-03-12 4 A 0 38643 0 A 2027-08-02 Common Stock 38643 38643 D Stock Option (right to buy) 2.39 2018-06-01 4 A 0 146804 0 A 2028-05-14 Common Stock 146804 146804 D Granted pursuant to the Issuer's 2014 Equity Incentive Plan All share numbers and the exercise price reflect the 1-for-15 reverse stock split effected on June 1, 2018. The option grant was approved by the Issuer's board of directors on August 2, 2017, subject to shareholder approval of the amendment to the 2014 Stock Incentive Plan. The Issuer's shareholders approved the amendment on March 12, 2018. Vests in equal monthly installments, beginning August 2, 2017, such that it is vested in full on the 3-year anniversary of the grant date. The option grant was approved by the Issuer's board of directors on May 14, 2018, subject to the stockholders approving and effecting a reverse stock split. The Issuer's shareholders approved the reverse stock split on May 18, 2018 and effected such stock split on June 1, 2018. Vests in equal monthly installments, beginning on May 14, 2018, such that it is vested in full on the 3-year anniversary of the grant date. /s/ Karen S. Wright, Attorney-in-Fact 2018-06-06