144 0001242825 XXXXXXXX LIVE 0000875320 Vertex Pharmaceuticals Incorporated 000-19319 50 NORTHERN AVENUE BOSTON MA 02210 6173416393 JEFFREY M LEIDEN Director Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

53604 23292010.08 253718831 11/14/2025 NASDAQ Common 11/14/2025 Exercise of Stock Options Issuer N 53604 11/14/2025 Cash N 10b5-1 Sales for JEFFREY M LEIDEN

50 NORTHERN AVENUE BOSTON MA 02210

Common 11/13/2025 19688 8668066.25 11/14/2025 08/06/2025 /s/ Jeffrey M Leiden