X0306 4 2020-06-30 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001242825 LEIDEN JEFFREY M C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 1 0 0 Executive Chairman Common Stock 2020-06-30 4 S 0 5801 284.14 D 29252 D Common Stock 2020-06-30 4 S 0 9233 285.11 D 20019 D Common Stock 2020-06-30 4 S 0 8321 286.13 D 11698 D Common Stock 2020-06-30 4 S 0 4885 287.23 D 6813 D Common Stock 2020-06-30 4 S 0 1318 287.91 D 5495 D Common Stock 2020-06-30 4 S 0 500 289.39 D 4995 D Common Stock 2020-06-30 4 S 0 2534 290.51 D 2461 D Common Stock 2020-06-30 4 S 0 200 291.34 D 2261 D Common Stock 440 I 401(k) Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $284.14 (range $283.60 to $284.59). Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $285.11 (range $284.70 to $285.66). Open market sales reported on this line occurred at a weighted average price of $286.13 (range $285.71 to $286.66). Open market sales reported on this line occurred at a weighted average price of $287.23 (range $286.74 to $287.73). Open market sales reported on this line occurred at a weighted average price of $287.91 (range $287.75 to $288.16). Open market sales reported on this line occurred at a weighted average price of $289.39 (range $289.07 to $289.99). Open market sales reported on this line occurred at a weighted average price of $290.51 (range $290.12 to $290.87). Open market sales reported on this line occurred at a weighted average price of $291.34 (range $291.31 to $291.36). /s/ Sabrina Yohai, Attorney-in-Fact 2020-07-02