X0306 4 2021-01-08 0 0001748907 Orchard Therapeutics plc ORTX 0001242616 THOMAS FRANK E C/O ORCHARD THERAPEUTICS PLC 108 CANNON STREET LONDON X0 EC4N 6EU UNITED KINGDOM 0 1 0 0 See Remarks Ordinary Shares 2021-01-08 4 A 0 10667 0.00 A 35787 D Ordinary Shares 2021-01-11 4 F 0 3706 6.72 D 32081 D The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share. On January 16, 2019, the Reporting Person was granted certain performance-based Restricted Share Units ("RSUs"), the vesting of which was subject to the achievement of certain performance criteria. As of the transaction date, the first of three performance criteria was met, resulting in the vesting of 10,667 RSUs. Represents shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of RSUs and does not represent a sale by the Reporting Person. Title: President & Chief Operating Officer /s/ Frank Thomas 2021-01-12