X0306 4 2022-03-31 0 0001534133 GRAYBUG VISION, INC. GRAY 0001241009 BREUIL ROBERT S C/O GRAYBUG VISION, INC. 203 REDWOOD SHORES PARKWAY, SUITE 620 REDWOOD CITY CA 94065 0 1 0 0 Chief Financial Officer Common Stock 2022-03-31 4 M 0 5000 A 22717 D Common Stock 2022-03-31 4 S 0 2188 1.25 D 20529 D Restricted Stock Units 2022-03-31 4 M 0 5000 0.00 D Common Stock 5000 50000 D Each RSU represents a contingent right to receive one share of the Issuer's common stock. Represents the aggregate number of shares sold by the Reporting Person to cover taxes and fees due upon the release and settlement of the Restricted Stock Units ("RSUs"). The Reporting Person did not sell or otherwise dispose of any of the shares reported on this Form 4 for any reason other than to cover required taxes and fees. The RSUs vested as to 1/12 of the total shares on March 4, 2022, but were not settled and issued until March 31, 2022. 1/12 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on September 4, 2024, subject to the continued service of the Reporting Person to the Issuer through each vesting date. The RSUs do not expire; they either vest or are canceled prior to vest date. /s/ Frederic Guerard, as Attorney-in-Fact for Robert S. Breuil 2022-04-04