<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-03-26</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001367705</issuerCik>
        <issuerName>MEDecision, Inc.</issuerName>
        <issuerTradingSymbol>MEDE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001281446</rptOwnerCik>
            <rptOwnerName>GREAT POINT PARTNERS LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>165 MASON STREET</rptOwnerStreet1>
            <rptOwnerStreet2>3RD FLOOR</rptOwnerStreet2>
            <rptOwnerCity>GREENWICH</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06830</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001239607</rptOwnerCik>
            <rptOwnerName>JAY JEFFREY R</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>GREAT POINT PARTNERS, LLC</rptOwnerStreet1>
            <rptOwnerStreet2>165 MASON STREET, 3RD FLOOR</rptOwnerStreet2>
            <rptOwnerCity>GREENWICH</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06830</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001397513</rptOwnerCik>
            <rptOwnerName>KROIN DAVID</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>GREAT POINT PARTNERS LLC</rptOwnerStreet1>
            <rptOwnerStreet2>165 MASON STREET, 3RD FLOOR</rptOwnerStreet2>
            <rptOwnerCity>GREENWICH</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06830</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>970542</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Biomedical Value Fund, L.P.</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>826755</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Biomedical Offshore Value Fund, Ltd.</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Great Point Partners, LLC (&quot;Great Point&quot;) is the investment manager of Biomedical Value Fund, L.P. (&quot;BVF&quot;), and by virtue of
 such status may be deemed to be the beneficial owner of the shares held by BVF (the &quot;BVF Shares&quot;).  Each of Dr. Jeffrey R.
 Jay, M.D. (&quot;Dr. Jay&quot;), as senior managing member of Great Point, and Mr. David Kroin (&quot;Mr. Kroin&quot;), as special managing
 member of Great Point, has voting and investment power with respect to the BVF Shares, and therefore may be deemed to be the
 beneficial owner of the BVF Shares.  Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares,
 except to the extent of their respective pecuniary interest, and this report shall not be deemed to be an admission that
 they are the beneficial owners of such securities.</footnote>
        <footnote id="F2">Great Point is the investment manager of Biomedical Offshore Value Fund, Ltd. (&quot;BOVF&quot;), and by virtue of such status may be
 deemed to be the beneficial owner of the shares held by BOVF (the &quot;BOVF Shares&quot;).  Each of Dr. Jay, as senior managing
 member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with
 respect to the BOVF Shares, and therefore may be deemed to be the beneficial owner of the BOVF Shares.  Great Point, Dr. Jay
 and Mr. Kroin disclaim beneficial ownership of the BOVF Shares, except to the extent of their respective pecuniary interest,
 and this report shall not be deemed to be an admission that they are the beneficial owners of such securities.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Great Point Partners, LLC By: Dr. Jeffrey R. Jay, M.D., Senior Managing Member</signatureName>
        <signatureDate>2008-05-23</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Dr. Jeffrey R. Jay, M.D.</signatureName>
        <signatureDate>2008-05-23</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Mr. David Kroin</signatureName>
        <signatureDate>2008-05-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
