X0202 4 2006-02-27 0 0000792977 ADVANCED MAGNETICS INC AVM 0001281446 GREAT POINT PARTNERS LLC 2 PICKWICK PLAZA STE 450 GREENWICH CT 06830 0 0 1 0 0001239607 JAY JEFFREY R GREAT POINT PARTNERS, LLC 2 PICKWICK PLAZA, SUITE 450 GREENWICH CT 06830 0 0 1 0 Common Stock 2006-02-27 4 S 0 2296 25.07 D 666436 I By Biomedical Value Fund, L.P. Common Stock 2006-02-27 4 S 0 2295 25.02 D 664141 I By Biomedical Value Fund, L.P. Common Stock 2006-02-27 4 S 0 2296 25.11 D 661845 I By Biomedical Value Fund, L.P. Common Stock 2006-02-27 4 S 0 2295 25.31 D 659550 I By Biomedical Value Fund, L.P. Common Stock 2006-02-27 4 S 0 13773 25.35 D 645777 I By Biomedical Value Fund, L.P. Common Stock 2006-02-27 4 S 0 2296 25.23 D 643481 I By Biomedical Value Fund, L.P. Common Stock 2006-02-27 4 S 0 2295 25.20 D 641186 I By Biomedical Value Fund, L.P. Common Stock 2006-02-27 4 S 0 2296 25.41 D 638890 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 1200 25.15 D 637690 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 240 25.12 D 637450 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 48 25.13 D 637402 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 336 25.10 D 637066 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 192 25.35 D 636874 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 96 25.26 D 636778 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 1200 25.25 D 635578 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 288 25.30 D 635290 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 480 25.29 D 634810 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 240 25.28 D 634570 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 48 25.06 D 634522 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 432 25.05 D 634090 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 144 25.30 D 633946 I By Biomedical Value Fund, L.P. Common Stock 2006-02-28 4 S 0 240 25.00 D 633706 I By Biomedical Value Fund, L.P. Common Stock 2006-02-27 4 S 0 204 25.07 D 710374 I By Biomedical Offshore Value Fund, Ltd. Common Stock 2006-02-27 4 S 0 205 25.02 D 710169 I By Biomedical Offshore Value Fund, Ltd. Common Stock 2006-02-27 4 S 0 204 25.11 D 709965 I By Biomedical Offshore Value Fund, Ltd. Common Stock 2006-02-27 4 S 0 205 25.31 D 709760 I By Biomedical Offshore Value Fund, Ltd. Common Stock 2006-02-27 4 S 0 1227 25.35 D 708533 I By Biomedical Offshore Value Fund, Ltd. Common Stock 2006-02-27 4 S 0 204 25.23 D 708329 I By Biomedical Offshore Value Fund, Ltd. Common Stock 2006-02-27 4 S 0 205 25.20 D 708124 I By Biomedical Offshore Value Fund, Ltd. Great Point Partners, LLC ("Great Point") is the investment manager of Biomedical Value Fund, L.P. ("BMVF") and by virtue of such status may be deemed to be the beneficial owner of the shares held by BMVF. Dr. Jeffrey R. Jay, M.D., as senior managing member of Great Point ("Dr. Jay"), has voting and investment power with respect to the shares held by BMVF and may be deemed to be the beneficial owner of the shares held by BMVF. Great Point and Dr. Jay disclaim beneficial ownership of the shares held by BMVF, except to the extent of any pecuniary interest, and this report shall not be deemed to be an admission that they are the beneficial owners of such securities. Great Point is the investment manager of Biomedical Offshore Value Fund, Ltd. ("BOVF") and by virtue of such status may be deemed to be the beneficial owner of the shares held by BOVF. Dr. Jay, as senior managing member of Great Point, has voting and investment power with respect to the shares held by BOVF and may be deemed to be the beneficial owner of the shares held by BOVF. Great Point and Dr. Jay disclaim beneficial ownership of the shares held by BOVF, except to the extent of any pecuniary interest, and this report shall not be deemed to be an admission that they are the beneficial owners of such securities. GREAT POINT PARTNERS, LLC By: /s/ Dr. Jeffrey R. Jay, M.D., as senior managing member 2006-03-02 /s/ Dr. Jeffrey R. Jay, M.D. 2006-03-02