-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001458177-11-000002.txt : 20110204
<SEC-HEADER>0001458177-11-000002.hdr.sgml : 20110204
<ACCEPTANCE-DATETIME>20110204173236
ACCESSION NUMBER:		0001458177-11-000002
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20110202
FILED AS OF DATE:		20110204
DATE AS OF CHANGE:		20110204

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ROBERTS BRYAN E
		CENTRAL INDEX KEY:			0001239242

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51462
		FILM NUMBER:		11575838

	MAIL ADDRESS:	
		STREET 1:		C/O VENROCK ASSOCIATES
		STREET 2:		2494 SAND HILL ROAD STE 200
		CITY:			MENLO PARK
		STATE:			CA
		ZIP:			94025

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Hove Anders D
		CENTRAL INDEX KEY:			0001365618

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51462
		FILM NUMBER:		11575839

	MAIL ADDRESS:	
		STREET 1:		30 ROCKEFELLER PLAZA, SUITE 5508
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10112

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Chelsea Therapeutics International, Ltd.
		CENTRAL INDEX KEY:			0001333763
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				203174202
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3530 TORINGDON WAY
		STREET 2:		SUITE 200
		CITY:			CHARLOTTE
		STATE:			NC
		ZIP:			28277
		BUSINESS PHONE:		704-341-1516

	MAIL ADDRESS:	
		STREET 1:		3530 TORINGDON WAY
		STREET 2:		SUITE 200
		CITY:			CHARLOTTE
		STATE:			NC
		ZIP:			28277

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			VENROCK HEALTHCARE CAPITAL PARTNERS LP
		CENTRAL INDEX KEY:			0001458177
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51462
		FILM NUMBER:		11575842

	BUSINESS ADDRESS:	
		STREET 1:		3340 HILLVIEW AVENUE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94306
		BUSINESS PHONE:		650-561-9580

	MAIL ADDRESS:	
		STREET 1:		3340 HILLVIEW AVENUE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94306

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			VHCP Co-Investment Holdings, LLC
		CENTRAL INDEX KEY:			0001479354
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51462
		FILM NUMBER:		11575841

	BUSINESS ADDRESS:	
		STREET 1:		3340 HILLVIEW AVENUE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304
		BUSINESS PHONE:		6504753734

	MAIL ADDRESS:	
		STREET 1:		3340 HILLVIEW AVENUE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			VHCP Management, LLC
		CENTRAL INDEX KEY:			0001479355
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51462
		FILM NUMBER:		11575840

	BUSINESS ADDRESS:	
		STREET 1:		3340 HILLVIEW AVENUE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304
		BUSINESS PHONE:		6504753734

	MAIL ADDRESS:	
		STREET 1:		3340 HILLVIEW AVENUE
		CITY:			PALO ALTO
		STATE:			CA
		ZIP:			94304
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2011-02-02</periodOfReport>

    <issuer>
        <issuerCik>0001333763</issuerCik>
        <issuerName>Chelsea Therapeutics International, Ltd.</issuerName>
        <issuerTradingSymbol>CHTP</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001458177</rptOwnerCik>
            <rptOwnerName>VENROCK HEALTHCARE CAPITAL PARTNERS LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O VENROCK</rptOwnerStreet1>
            <rptOwnerStreet2>3340 HILLVIEW AVENUE</rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94304</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001479354</rptOwnerCik>
            <rptOwnerName>VHCP Co-Investment Holdings, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O VENROCK</rptOwnerStreet1>
            <rptOwnerStreet2>3340 HILLVIEW AVENUE</rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94304</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001479355</rptOwnerCik>
            <rptOwnerName>VHCP Management, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O VENROCK</rptOwnerStreet1>
            <rptOwnerStreet2>3340 HILLVIEW AVENUE</rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94304</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001365618</rptOwnerCik>
            <rptOwnerName>Hove Anders D</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O VENROCK</rptOwnerStreet1>
            <rptOwnerStreet2>530 FIFTH AVENUE, 22ND FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001239242</rptOwnerCik>
            <rptOwnerName>ROBERTS BRYAN E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O VENROCK</rptOwnerStreet1>
            <rptOwnerStreet2>3340 HILLVIEW AVENUE</rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94304</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2011-02-02</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>75000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>4.9999</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5189934</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Fund</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Consists of 4,387,367 shares of common stock held directly by Venrock Healthcare Capital Partners, L.P. (&quot;VHCP&quot;) and 802,567 shares of common stock held directly by VHCP Co-Investment Holdings, LLC (&quot;VHCP Co-Investment&quot;). VHCP Management, LLC (&quot;VHCP Management&quot;) is the general partner of VHCP and VHCP Co-Investment and may be deemed to beneficially own these shares. Messrs. Anders Hove and Bryan Roberts are the managing members of VHCP Management and may be deemed to beneficially own these shares. Each reporting person disclaims beneficial ownership of these shares, except to the extent of his or its respective pecuniary interest therein.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ David L. Stepp, Authorized Signatory</signatureName>
        <signatureDate>2011-02-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ David L. Stepp, Authorized Signatory</signatureName>
        <signatureDate>2011-02-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ David L. Stepp, Authorized Signatory</signatureName>
        <signatureDate>2011-02-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ David L. Stepp, as attorney-in-fact</signatureName>
        <signatureDate>2011-02-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ David L. Stepp, as attorney-in-fact</signatureName>
        <signatureDate>2011-02-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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