<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
	<headerData>
        <submissionType>144</submissionType>
                <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001239127</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
        <liveTestFlag>LIVE</liveTestFlag>




                </filerInfo>
    </headerData>

     <formData>
        <issuerInfo>
            <issuerCik>0001551152</issuerCik>
			<issuerName>ABBVIE INC.</issuerName>


			    <secFileNumber>001-35565</secFileNumber>


			<issuerAddress>
				<com:street1>1 NORTH WAUKEGAN ROAD</com:street1>
                				<com:city>NORTH CHICAGO</com:city>
				<com:stateOrCountry>IL</com:stateOrCountry>
				<com:zipCode>60064</com:zipCode>
			</issuerAddress>

			<issuerContactPhone>(847) 932-7900</issuerContactPhone>
			<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Richard A. Gonzalez</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>

			<relationshipsToIssuer>
                                                                                                    <relationshipToIssuer>Former Director</relationshipToIssuer>

			</relationshipsToIssuer>
		</issuerInfo>

				          <securitiesInformation>
			<securitiesClassTitle>Common</securitiesClassTitle>
			<brokerOrMarketmakerDetails>
				<name>Northern Trust Securities, Inc.</name>
				<address>
				<com:street1>50 S. LaSalle Street, B-2</com:street1>
                				<com:city>Chicago</com:city>
				<com:stateOrCountry>IL</com:stateOrCountry>
				<com:zipCode>60603</com:zipCode>
				</address>
			</brokerOrMarketmakerDetails>
			<noOfUnitsSold>61500</noOfUnitsSold>
			<aggregateMarketValue>12043268.25</aggregateMarketValue>
			<noOfUnitsOutstanding>1766558253</noOfUnitsOutstanding>
			<approxSaleDate>08/01/2025</approxSaleDate>
			<securitiesExchangeName>NYSE</securitiesExchangeName>
		</securitiesInformation>
                     <securitiesInformation>
			<securitiesClassTitle>Common</securitiesClassTitle>
			<brokerOrMarketmakerDetails>
				<name>Northern Trust Securities, Inc.</name>
				<address>
				<com:street1>50 S. LaSalle Street, B-2</com:street1>
                				<com:city>Chicago</com:city>
				<com:stateOrCountry>IL</com:stateOrCountry>
				<com:zipCode>60603</com:zipCode>
				</address>
			</brokerOrMarketmakerDetails>
			<noOfUnitsSold>35120</noOfUnitsSold>
			<aggregateMarketValue>6828296.22</aggregateMarketValue>
			<noOfUnitsOutstanding>1766558253</noOfUnitsOutstanding>
			<approxSaleDate>08/04/2025</approxSaleDate>
			<securitiesExchangeName>NYSE</securitiesExchangeName>
		</securitiesInformation>
                     <securitiesInformation>
			<securitiesClassTitle>Common</securitiesClassTitle>
			<brokerOrMarketmakerDetails>
				<name>Northern Trust Securities, Inc.</name>
				<address>
				<com:street1>50 S. LaSalle Street, B-2</com:street1>
                				<com:city>Chicago</com:city>
				<com:stateOrCountry>IL</com:stateOrCountry>
				<com:zipCode>60603</com:zipCode>
				</address>
			</brokerOrMarketmakerDetails>
			<noOfUnitsSold>91600</noOfUnitsSold>
			<aggregateMarketValue>19208000</aggregateMarketValue>
			<noOfUnitsOutstanding>1766558253</noOfUnitsOutstanding>
			<approxSaleDate>08/04/2025</approxSaleDate>
			<securitiesExchangeName>NYSE</securitiesExchangeName>
		</securitiesInformation>

    		       <securitiesToBeSold>
         <securitiesClassTitle>Common</securitiesClassTitle>
         <acquiredDate>02/27/2019</acquiredDate>
         <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>31977</amountOfSecuritiesAcquired>
                  <paymentDate>02/27/2019</paymentDate>
                  <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
             <securitiesToBeSold>
         <securitiesClassTitle>Common</securitiesClassTitle>
         <acquiredDate>02/28/2020</acquiredDate>
         <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>9523</amountOfSecuritiesAcquired>
                  <paymentDate>02/28/2020</paymentDate>
                  <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
             <securitiesToBeSold>
         <securitiesClassTitle>Common</securitiesClassTitle>
         <acquiredDate>02/26/2021</acquiredDate>
         <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>20000</amountOfSecuritiesAcquired>
                  <paymentDate>02/26/2021</paymentDate>
                  <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
             <securitiesToBeSold>
         <securitiesClassTitle>Common</securitiesClassTitle>
         <acquiredDate>02/28/2017</acquiredDate>
         <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>538</amountOfSecuritiesAcquired>
                  <paymentDate>02/28/2017</paymentDate>
                  <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
             <securitiesToBeSold>
         <securitiesClassTitle>Common</securitiesClassTitle>
         <acquiredDate>02/27/2019</acquiredDate>
         <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>34582</amountOfSecuritiesAcquired>
                  <paymentDate>02/27/2019</paymentDate>
                  <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>
             <securitiesToBeSold>
         <securitiesClassTitle>Common</securitiesClassTitle>
         <acquiredDate>02/28/2017</acquiredDate>
         <natureOfAcquisitionTransaction>Restricted Stock</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>91600</amountOfSecuritiesAcquired>
                  <paymentDate>02/28/2017</paymentDate>
                  <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>

    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>


    		<remarks>This Form 144 reflects the intended deemed sale of 91,600 shares of AbbVie's common stock which are subject to call options sold on August 4, 2025.</remarks>

        <noticeSignature>
            <noticeDate>08/08/2025</noticeDate>
                        <signature> T.O. Odutayo, Attorney-in-Fact for Richard A. Gonzalez</signature>
        </noticeSignature>
	</formData>
    </edgarSubmission>
