<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2016-09-28</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001011835</issuerCik>
        <issuerName>MEDIVATION, INC.</issuerName>
        <issuerTradingSymbol>MDVN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001238913</rptOwnerCik>
            <rptOwnerName>BLICKENSTAFF KIM D</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MEDIVATION, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>525 MARKET ST., 36TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

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    </nonDerivativeTable>

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        <derivativeTransaction>
            <securityTitle>
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            </securityTitle>
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            </conversionOrExercisePrice>
            <transactionDate>
                <value>2016-09-28</value>
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            <deemedExecutionDate></deemedExecutionDate>
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            <transactionTimeliness>
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                <transactionShares>
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                <transactionPricePerShare>
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            <exerciseDate>
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            <expirationDate>
                <value>2023-06-28</value>
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            <underlyingSecurity>
                <underlyingSecurityTitle>
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                </underlyingSecurityTitle>
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        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Non-Qualified Stock Option (right to buy)</value>
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            <conversionOrExercisePrice>
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            <transactionDate>
                <value>2016-09-28</value>
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            <deemedExecutionDate></deemedExecutionDate>
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            <expirationDate>
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                <value></value>
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        <derivativeTransaction>
            <securityTitle>
                <value>Non-Qualified Stock Option (right to buy)</value>
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                <value>2026-06-22</value>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
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    </derivativeTable>

    <footnotes>
        <footnote id="F1">Disposed of pursuant to an Agreement and Plan of Merger (the &quot;Merger Agreement&quot;), dated August 20, 2016, among the Issuer, Pfizer Inc., a Delaware corporation (&quot;Parent&quot;), and Montreal, Inc., a Delaware corporation and a wholly-owned subsidiary of Parent (&quot;Purchaser&quot;), in exchange for a cash consideration of $81.50 per share (without interest) subject to any required withholding of taxes. Pursuant to the Merger Agreement, the Purchaser merged with and into the Issuer, with the Issuer surviving as a wholly-owned subsidiary of Parent (the &quot;Merger&quot;). In connection with the Merger, Purchaser offered to purchase all of the outstanding shares of common stock, par value $0.01 per share of the Issuer, at a price of $81.50 per share, net to the seller in cash (without interest) but subject to any required withholding of taxes, upon the terms and conditions set forth in the offer to purchase dated August 30, 2016, and in the related letter of transmittal.</footnote>
        <footnote id="F2">Includes 2,972 unvested shares subject to a restricted stock award.</footnote>
        <footnote id="F3">This option was cancelled in the Merger in exchange for a cash payment equal to $81.50 per share (without interest) subject to any required withholding of taxes minus the per share exercise price of the option. In connection with the Merger, vesting of the option was accelerated and the option became fully vested and exercisable effective immediately prior to the effective time of the Merger.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Carolyn Tang, Attorney-in-fact</signatureName>
        <signatureDate>2016-09-30</signatureDate>
    </ownerSignature>
</ownershipDocument>
