X0303 4 2010-01-03 0 0000873303 AVI BIOPHARMA INC AVII 0001237656 WELLER DWIGHT D 4575 SW RESEARCH WAY, SUITE 200 CORVALLIS OR 97333 0 1 0 0 Sr. VP Chemistry & Mfg. Common Stock 314741 D Common Stock 24936 I by Spouse Incentive Stock Option (right to buy) 1.45 2010-02-09 4 A 0 110575 0 A 2011-02-09 2020-02-09 Common Stock 110575 110575 D Incentive Stock Option (right to buy) 5.75 2010-01-03 4 J 0 52173 0 D 2001-01-03 2010-01-03 Common Stock 52173 0 D Incentive Stock Option (right to buy) 1.49 2010-02-08 4 A 0 14000 0 A 2011-02-08 2020-02-08 Common Stock 14000 14000 I by Spouse Non-Qualified Stock Option (right to buy) 1.45 2010-02-09 4 A 0 9425 0 A 2011-02-09 2020-02-09 Common Stock 9425 9425 D Non-Qualified Stock Option (right to buy) 5.75 2010-01-03 4 J 0 31827 0 D 2001-01-03 2010-01-03 Common Stock 31827 0 D Incentive Stock Option (right to buy) 0.92 2010-02-10 2019-02-10 Common Stock 93839 93839 D Incentive Stock Option (right to buy) 1.39 2009-02-28 2018-02-28 Common Stock 17985 17985 D Incentive Stock Option (right to buy) 2.53 2006-02-22 2015-02-22 Common Stock 75000 75000 D Incentive Stock Option (right to buy) 3 2009-02-06 2017-02-06 Common Stock 25001 25001 D Incentive Stock Option (right to buy) 5.35 2003-12-05 2012-12-05 Common Stock 37382 37382 D Incentive Stock Option (right to buy) 7.35 2007-02-16 2016-02-16 Common Stock 23605 23605 D Incentive Stock Option (right to buy) 0.92 2010-02-10 2019-02-10 Common Stock 18000 18000 I by Spouse Incentive Stock Option (right to buy) 1.15 2009-06-12 2018-06-12 Common Stock 23000 23000 I by Spouse Incentive Stock Option (right to buy) 1.39 2008-02-28 2013-02-28 Common Stock 5316 5316 I by Spouse Incentive Stock Option (right to buy) 2.53 2005-02-22 2010-02-22 Common Stock 4921 4921 I by Spouse Incentive Stock Option (right to buy) 3 2007-02-06 2017-02-06 Common Stock 4567 4567 I by Spouse Incentive Stock Option (right to buy) 7.35 2006-02-16 2011-02-16 Common Stock 2782 2782 I by Spouse Non-Qualified Stock Option (right to buy) 0.92 2010-02-10 2019-02-10 Common Stock 6161 6161 D Non-Qualified Stock Option (right to buy) 1.39 2009-02-28 2018-02-28 Common Stock 57015 57015 D Non-Qualified Stock Option (right to buy) 3 2008-02-06 2017-02-06 Common Stock 49999 49999 D Non-Qualified Stock Option (right to buy) 5.35 2003-12-05 2012-12-05 Common Stock 55018 55018 D Non-Qualified Stock Option (right to buy) 7.35 2007-02-16 2016-02-16 Common Stock 51395 51395 D Amount of Securities Beneficially Owned include shares purchased under the Company's registered Employee Stock Purchase Plan. The Stock Option Grant vest as follows: 1/3 vest one year from date of grant and 1/3 each year thereafter until all shares vest three years from grant date. Price not required on initial report of stock option granted. All shares expired. Grant vest 100% on grant date. Dwight Weller 2010-02-11