X0202 4 2008-02-02 0 0000873303 AVI BIOPHARMA INC AVII 0001237656 WELLER DWIGHT D ONE SW COLUMBIA, SUITE 1105 PORTLAND OR 97258 0 1 0 0 Sr. VP Chemistry & Mfg. Common Stock 285822 D Common Stock 24936 I by Spouse Incentive Stock Option (right to buy) 1.39 2008-02-28 4 A 0 17985 0 A 2009-02-28 2018-02-28 Common Stock 17985 17985 D Incentive Stock Option (right to buy) 6.625 2008-02-02 4 J 0 45281 0 D 1998-02-02 2008-02-02 Common Stock 45281 0 D Incentive Stock Option (right to buy) 1.39 2008-02-28 4 A 0 5316 0 A 2008-02-28 2013-02-28 Common Stock 5316 5316 I by Spouse Non-Qualified Stock Option (right to buy) 1.39 2008-02-28 4 A 0 57015 0 A 2009-02-28 2018-02-28 Common Stock 57015 57015 D Non-Qualified Stock Option (right to buy) 6.625 2008-02-02 4 J 0 38719 0 D 1998-02-02 2008-02-02 Common Stock 38719 0 D Incentive Stock Option (right to buy) 2.53 2006-02-22 2015-02-22 Common Stock 75000 75000 D Incentive Stock Option (right to buy) 3 2009-02-06 2017-02-06 Common Stock 25001 25001 D Incentive Stock Option (right to buy) 5.35 2003-12-05 2012-12-05 Common Stock 37382 37382 D Incentive Stock Option (right to buy) 5.75 2001-01-03 2010-01-03 Common Stock 52173 52173 D Incentive Stock Option (right to buy) 7.35 2007-02-16 2016-02-16 Common Stock 23605 23605 D Incentive Stock Option (right to buy) 2.53 2005-02-22 2010-02-22 Common Stock 4921 4921 I by Spouse Incentive Stock Option (right to buy) 3 2007-02-06 2017-02-06 Common Stock 4567 4567 I by Spouse Incentive Stock Option (right to buy) 3.81 1999-08-24 2008-08-24 Common Stock 10000 10000 I by Spouse Incentive Stock Option (right to buy) 4.34 2004-01-22 2009-01-22 Common Stock 2682 2682 I by Spouse Incentive Stock Option (right to buy) 7.35 2006-02-16 2011-02-16 Common Stock 2782 2782 I by Spouse Non-Qualified Stock Option (right to buy) 3 2008-02-06 2017-02-06 Common Stock 49999 49999 D Non-Qualified Stock Option (right to buy) 5.35 2003-12-05 2012-12-05 Common Stock 55018 55018 D Non-Qualified Stock Option (right to buy) 5.75 2001-01-03 2010-01-03 Common Stock 31827 31827 D Non-Qualified Stock Option (right to buy) 7.35 2007-02-16 2016-02-16 Common Stock 51395 51395 D Amount of Securities Beneficially Owned include shares purchased under the Company's registered Employee Stock Purchase Plan. The Stock Option Grant vest as follows: 1/3 vest one year from date of grant and 1/3 each year thereafter until all shares vest three years from grant date. All shares expired. Grant vest 100% on grant date. Vesting: 25% of the shares vest each year from the date of grant with all shares vesting in four years. By: Mark M. Webber, Attorney-in-fact For: Dwight Weller 2008-03-03