X0303 4 2010-02-03 0000901219 HUMAN GENOME SCIENCES INC HGSI 0001237409 BARABE TIMOTHY C 14200 SHADY GROVE ROAD ROCKVILLE MD 20850 1 Chief Financial Officer Common Stock 2010-02-03 4 M 0 22907 0.52 A 62580.84 D Common Stock 2010-02-03 4 M 0 5416 10.11 A 67996.84 D Common Stock 2010-02-03 4 M 0 6 0.52 A 68002.84 D Common Stock 2010-02-03 4 S 0 22907 27.9164 D 45095.84 D Employee Stock Option - Right to Buy 10.11 2010-02-03 4 M 0 5416 0 D 2016-07-10 Common Stock 5416 224911 D Employee Stock Option - Right to Buy 0.52 2010-02-03 4 M 0 6 0 D 2019-03-10 Common Stock 6 109994 D Employee Stock Option - Right to Buy 0.52 2010-02-03 4 M 0 22907 0 D 2019-03-10 Common Stock 22907 87087 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person and Charles Schwab effective 12/9/09. This transaction was executed in multiple trades at prices ranging from $27.71 to $28.09. The price reported above reflects the weighted average sale price. Upon written request by the Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price is available. One fourth of the options granted vested on July 10, 2007, the one-year anniversary date of the grant, and the remaining options vested monthly, and continue to vest monthly on a ratable basis for the next 36 months beginning on August 10, 2007. These are vested and exercisable. One eighth of the options granted on March 10, 2009 vested on the six-month anniversary date (Sept 10, 2009) and the remaining options granted vested monthly, and continue to vest monthly on a ratable basis for the next 42 months commencing on October 10, 2009. /s/ Timothy Barabe 2010-02-04