X0206 3 2018-09-25 0 0001724344 Entasis Therapeutics Holdings Inc. ETTX 0001237401 HASTINGS DAVID C C/O ENTASIS THERAPEUTICS HOLDINGS INC. 35 GATEHOUSE DRIVE WALTHAM MA 02451 1 0 0 0 Stock Option (Right to Buy) 6.85 2028-04-30 Common Stock 12060 D Twenty-five percent (25%) of the shares subject to the option shall vest on May 1, 2019, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter on the last day of the month, subject to Reporting Person continuing to provide service through each such date. Exhibit List: Exhibit 24 - Power of Attorney /s/ Christian Plaza, Attorney-in-Fact 2018-09-25