X0306 4 2020-04-03 0 0001563880 Trevi Therapeutics, Inc. TRVI 0001237289 SANDELL SCOTT D 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM MD 21093 0 0 1 0 Common Stock 2020-04-03 4 X 0 1500000 0.001 A 5938562 I See Note 1 Common Stock 2020-04-03 4 S 0 564 2.66 D 5937998 I See Note 1 Call Option (right to buy) 0.001 2020-04-03 4 X 0 1500000 0.00 D 2019-05-09 2022-05-06 Common Stock 1500000 0 I See Note 1 The Reporting Person is a manager of NEA 16 GP, LLC which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest. On April 3, 2020, NEA 16 exercised a call option to purchase 1,500,000 shares of the Issuer's common stock ("Common Stock") for $0.001 per share. NEA 16 paid the exercise price through the forfeiture of 564 shares of Common Stock. The call option became exercisable upon the closing of the Issuer's initial public offering. /s/ Sasha Keough, Attorney-in-Fact 2020-04-13