X0206 3 2018-01-01 0 0001634432 Strongbridge Biopharma plc SBBP 0001237289 SANDELL SCOTT D 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM MD 21093 0 0 1 0 Ordinary Shares, $0.01 par value 4141308 I See Note 1 Ordinary Shares Warrant (right to buy) 2.50 2017-06-28 2022-06-28 Ordinary Shares, $0.01 par value 1000000 I See Note 1 The Reporting Person is a Director of NEA 14 GP, LTD, which is the sole general partner of NEA Partners 14, L.P. ("NEA Partners 14"). NEA Partners 14 is the sole general partner of New Enterprise Associates 14, L.P. ("NEA 14"). NEA 14 is the sole member of Growth Equity Opportunities Fund III, LLC ("GEO") , the direct beneficial owner of the Shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of the Shares held by GEO, except to the extent of his pecuniary interest therein. /s/ Sasha Keough, attorney-in-fact 2018-01-09