X0306 4 2013-06-05 0 0001571498 Epizyme, Inc. EPZM 0001237289 SANDELL SCOTT D 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM MD 21093 0 0 1 0 Common Stock 2013-06-05 4 C 0 5633240 A 5633240 I See Note 2 Common Stock 2013-06-05 4 P 0 400000 15 A 6033240 I See Note 2 Series B Preferred Stock 2013-06-05 4 C 0 16899721 D Common Stock 5633240 0 I See Note 2 Each share of Series B Preferred Stock automatically converted into 1/3rd of a share of Common Stock of the Issuer, upon the closing of the Issuer's initial public offering without payment of further consideration and had no expiration date. The Reporting Person is a director of NEA 13 GP, LTD, which is the sole general partner of NEA Partners 13, L.P. ("NEA Partners 13"). NEA Partners 13 is the sole general partner of New Enterprise Associates 13, L.P. ("NEA 13"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of the securities held by NEA 13, except to the extent of his pecuniary interest therein. /s/ Louis Citron, attorney-in-fact 2013-06-07