X0303 4 2009-11-11 1 0001408808 PEPLIN INC PLIN 0001383391 New Enterprise Associates 12, Limited Partnership 1119 ST. PAUL STREET BALTIMORE MD 21202 0 0 1 0 0001383389 NEA 12 GP, LLC 1119 ST. PAUL ST. BALTIMORE MD 21202 0 0 1 0 0001383390 NEA Partners 12, Limited Partnership 1119 ST. PAUL ST. BALTIMORE MD 21202 0 0 1 0 0001005544 NEWHALL CHARLES W III 1119 ST. PAUL STREET BALTIMORE MD 21202 0 0 1 0 0001005550 KRAMLICH C RICHARD 1119 ST. PAUL STREET BALTIMORE MD 21202 0 0 1 0 0001005561 BARRIS PETER J 1119 ST. PAUL STREET BALTIMORE MD 21202 0 0 1 0 0001062466 PERRY MARK W 1119 ST. PAUL STREET BALTIMORE MD 21202 0 0 1 0 0001219855 BARRETT M JAMES 1119 ST. PAUL STREET BALTIMORE MD 21202 0 0 1 0 0001237289 SANDELL SCOTT D 1119 ST. PAUL STREET BALTIMORE MD 21202 0 0 1 0 0001172932 TRAINOR III EUGENE A 1119 ST. PAUL STREET BALTIMORE MD 21202 0 0 1 0 Common Stock 2009-11-11 4 U 0 1301781.55 16.99 D 0 D Common Stock Warrant (Right to Buy) 7.86 2009-11-11 4 U 0 264608 9.13 D 2008-10-23 2013-10-23 Common Stock 264608 0 D The securities are directly held by New Enterprise Associates 12, Limited Partnership ("NEA 12") and indirectly held by NEA Partners 12, Limited Partnership ("NEA Partners 12"), the sole general partner of NEA 12, NEA 12 GP, LLC ("NEA 12 GP"), the sole general partner of NEA Partners 12, and the individual managers of NEA 12 GP (NEA Partners 12, NEA 12 GP and the individual managers of NEA 12 GP, together, the "Indirect Reporting Persons"). The individual managers of NEA 12 GP are M. James Barrett, Peter J. Barris, Forest Baskett, Ryan D. Drant, Patrick J. Kerins, C. Richard Kramlich, Krishna "Kittu" Kolluri, Charles M. Linehan, Charles W. Newhall III, Mark W. Perry, Scott D. Sandell and Eugene A. Trainor III. The Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended (the "1934 Act"), or otherwise of the securities of the issuer held by NEA 12, except to the extent of such Indirect Reporting Person's pecuniary interest therein, if any. The securities are directly held by NEA 12 and indirectly held by the Indirect Reporting Persons. The Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the 1934 Act or otherwise of the securities of the issuer held by NEA 12, except to the extent of such Indirect Reporting Person's pecuniary interest therein, if any. As a result of the disposition of securities of the issuer, NEA 12 no longer owns 10% or more of the outstanding common stock of the issuer and, accordingly, is no longer currently subject to reporting requirements or other obligations under Section 16 of the 1934 Act with respect to ownership of the common stock of the issuer which, in turn, means that the Indirect Reporting Persons also are no longer subject to such provisions of the 1934 Act. /s/ Louis Citron, attorney-in-fact 2009-11-13