X0306 4 2016-06-22 0 0001401914 Cerulean Pharma Inc. CERU 0001237262 MCKEE WILLIAM C/O CERULEAN PHARMA INC. 35 GATEHOUSE DRIVE WALTHAM MA 02451 1 0 0 0 Stock Option (right to buy) 2.08 2016-06-22 4 A 0 20000 0.00 A 2026-06-21 Common Stock 20000 20000 D This option was granted on June 22, 2016. The shares underlying such option vest in full on the earlier of June 22, 2017 or immediately prior to the Corporation's 2017 annual meeting of stockholders, subject to the reporting person's continued service as a director of the Corporation through such date. /s/ Alejandra Carvajal, as attorney-in-fact for William T. McKee 2016-06-24