X0306 4 2015-06-26 0 0001401914 Cerulean Pharma Inc. CERU 0001237262 MCKEE WILLIAM C/O CERULEAN PHARMA INC. 840 MEMORIAL DRIVE CAMBRIDGE MA 02139 1 0 0 0 Stock Option (Right to Buy) 4.78 2015-06-26 4 A 0 8214 0.00 A 2025-06-25 Common Stock 8214 8214 D Stock Option (Right to Buy) 4.78 2015-06-26 4 A 0 11000 0.00 A 2025-06-25 Common Stock 11000 11000 D This option was granted June 26, 2015. One-third of the shares underlying this option were vested on the date of grant and the remaining shares vest in two equal parts on the second and third anniversaries of the date Mr. McKee was elected to serve as a director of the Company, January 27, 2016 and January 27, 2017, respectively. This option was granted on June 26, 2015. The shares vest in full on the earlier of June 26, 2016 or immediately prior to the Corporation's 2016 annual meeting of stockholders, subject to Mr. McKee's service as a director of the Corporation through such date. /s/Alejandra Carvajal, as attorney-in-fact for William McKee 2015-06-30